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Table 2 The effects of vitamin D supplementation on endothelial activation

From: The effects of vitamin D supplementation on endothelial activation among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials

Variable Number of study Standardized mean difference CI 95% Heterogeneity
I2 (%) Q P-value
VWF
 Change intervention group vs. placebo group 7 -0.27 −0.46, − 0.08 40.5 10.08 0.12
ICAM-1
 Intervention group (after vs. before) 4 −0.19 − 0.45, 0.06 18.9 3.70 0.29
 Placebo group (after vs. before) 4 3.51 1.28, 5.73 97.6 124.47 < 0.001
 Change intervention group vs. placebo group 5 −1.96 −4.02, 0.09 97.4 153.96 < 0.001
VCAM-1
 Intervention group (after vs. before) 6 −0.24 −0.44, −0.03 0.0 1.18 0.94
 Placebo group (after vs. before) 6 −0.08 − 0.49, 0.33 76.5 21.32 0.001
 Change intervention group vs. placebo group 7 −0.50 −1.19, 0.19 91.2 68.54 < 0.001
E-selectin
 Intervention group (after vs. before) 8 −0.25 −0.41, − 0.08 0.0 6.15 0.52
 Placebo group (after vs. before) 8 −0.10 −0.37, 0.17 66.0 20.56 0.004
 Change intervention group vs. placebo group 10 −0.04 −0.36, 0.28 78.8 42.49 < 0.001
Endothelin
 Intervention group (after vs. before) 4 −0.45 − 0.66, − 0.24 40.1 5.01 0.17
 Placebo group (after vs. before) 4 0.11 −0.10, 0.31 0.0 2.98 0.39
 Change intervention group vs. placebo group 4 −0.49 −1.18, 0.19 90.5 31.46 < 0.001
  1. VWF von willebrand factor, ICAM-1 intercellular adhesion molecule 1, VCAM-1 vascular cell adhesion molecule 1