Table 2 Metabolic parameters, GIR_60–120 at euglycemic clamp and ectopic triglyceride contents at the end of CR and during refeeding

Serum NEFA (μmol/l)

357.8 ± 34.4

349.1 ± 21.6

344.8 ± 43.7

422.4 ± 19.8*

362.1 ± 17.2

564.6 ± 43.7^†

360.6 ± 12.4

688.1 ± 33.7^†

363.5 ± 20.4

758.6 ± 45.0^†

Serum glucose (mmol/l)

4.90 ± 0.45

4.77 ± 0.35

4.93 ± 0.39

5.13 ± 0.24

5.03 ± 0.15

5.18 ± 0.28

4.95 ± 0.52

5.15 ± 0.66

4.87 ± 0.39

5.02 ± 0.30

Serum insulin (pmol/l)

104.6 ± 2.7

97.1 ± 10.0

94.2 ± 3.0

91.6 ± 9.6

97.4 ± 11.8

102.4 ± 3.1

100.8 ± 3.6

140.1 ± 11.5^†

105.2 ± 5.3

163.6 ± 16.3^†

GIR_60–120(mg·min⁻¹·kg⁻¹)

23.47 ± 0.89

25.34 ± 1.16

22.15 ± 1.44

24.15 ± 1.12

21.77 ± 1.38

23.30 ± 0.94

21.45 ± 1.20

14.27 ± 1.06*

21.43 ± 1.05

12.00 ± 1.64*

HOMA-IR

3.17 ± 0.21

2.86 ± 0.15

2.93 ± 0.14

2.88 ± 0.21

3.06 ± 0.27

3.13 ± 0.12

3.16 ± 0.16

4.73 ± 0.14^†

3.11 ± 0.08

5.15 ± 0.39^†

Intramuscular triglyceride (mg/g tissue)

7.05 ± 1.34

6.24 ± 1.79

6.54 ± 1.47

6.68 ± 0.91

6.42 ± 1.15

7.04 ± 0.91

7.23 ± 0.89

10.13 ± 0.90^†

7.44 ± 0.64

12.16 ± 1.39^†

Intrahepatic triglyceride (mg/g tissue)

11.10 ± 1.94

9.66 ± 1.77

10.85 ± 1.90

10.97 ± 2.92

11.37 ± 1.85

15.96 ± 2.36

13.53 ± 2.55

30.13 ± 5.80^†

11.47 ± 1.70

36.03 ± 3.68^†