Role of PCK1 gene on oil tea-induced glucose homeostasis and type 2 diabetes: an animal experiment and a case-control study

Table 2 The association between the rs707555 and rs2071023 in PCK1 and type 2 diabetes, FBG and TG

Chr/gene	SNP	Allele frequency	Genotype	N	Association with type 2 diabetes		Association with FBG		Association with TG
					OR (95% CI)	*p-value	Coef. (95% CI)	*p-value	Coef. (95%CI)	& P-value
chr20/PCK1	rs707555	C (76.62%)	GG	215	ref		ref		ref
			GC	137	0.38 (0.20, 0.71)	0.002	−0.67 (−1.20, -0.13)	0.015	−0.06 (− 0.28, 0.16)	0.60
		G (23.38%)	CC	18	0.18 (0.05, 1.20)	0.08	−0.79 (−2.03, 0.44)	0.21	−0.39 (− 0.90, 0.11)	0.12
						p-trend = 0.001		p-trend = 0.01		p-trend = 0.20
chr20/PCK1	rs2071023	C (65.73%)	CC	153	ref		ref		ref
			CG	183	1.94 (1.06, 3.58)	0.03	0.51 (−0.03, 1.06)	0.07	0.10(−0.13, 0.32)	0.40
		G (34.27%)	GG	36	2.39 (0.92, 6.22)	0.07	0.30 (−0.61, 1.21)	0.52	0.47 (0.10, 0.85)	0.013
						p-trend = 0.022		p-trend = 0.17		p-trend = 0.027

*p-value adjusted for age, sex, BMI, family-history of diabetes, TG and TC
&p-value adjusted for age, sex, BMI and TC
Chr chrome, SNP single nucleotide polymorphism, PCK1 Phosphoenolpyruvate carboxykinase 1, FBG fasting blood glucose, BMI body mass index, TG triglyceride, TC total cholesterol

ISSN: 1743-7075