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Fig. 6 | Nutrition & Metabolism

Fig. 6

From: Resveratrol attenuates oxidative injury in human umbilical vein endothelial cells through regulating mitochondrial fusion via TyrRS-PARP1 pathway

Fig. 6

Proposed mechanism for RSV in the regulation of PA-induced oxidative stress in HUVECs. Under the stimulation of PA, HUVECs suffer from oxidative stress. In the treatment of RSV, TyrRS-PARP1 pathway is activated, which then promotes the expression of mitochondrial fusion proteins (OPA1, MFN1/2). The enhancing of mitochondrial fusion finally reduces the oxidative stress in HUVECs

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