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Fig. 10 | Nutrition & Metabolism

Fig. 10

From: Stingless bee honey protects against lipopolysaccharide induced-chronic subclinical systemic inflammation and oxidative stress by modulating Nrf2, NF-κB and p38 MAPK

Fig. 10

SBH attenuates histological alterations in the liver, kidney, heart and lung of LPS-induced rats. Microscopic examination of H&E-stained sections of the control and 9.3 g/kg SBH-supplemented rats revealed normal histological structure of the liver, kidney, heart and lung. In contrast, liver sections of the LPS-induced rats showed an increase in lymphocytes (arrow heads) and neutrophils (arrows) infiltration and necrosis (circle). LPS-induced rats received 4.6 or 9.3 g/kg SBH showed a significant reduction in lymphocyte (arrow heads) and neutrophils (arrows) infiltration and improved liver histology. The kidney of LPS-induced rats showed infiltration of lymphocytes (arrow heads) and neutrophils (arrows), renal granuloma (circle) and degeneration of tubular cells. SBH-supplemented LPS-induced rats showed significantly reduced infiltration of lymphocytes (arrow heads) and neutrophils (arrows). The heart sections of LPS-induced rats showed degeneration of cardiomyocytes and infiltration of lymphocytes (arrow heads) and neutrophils (arrows), and the lung sections revealed edema, alveolar wall thickness and lymphocytes (arrow heads) and neutrophils (arrows) infiltration. Treatment of the LPS-induced rats with 4.6 or 9.3 g/kg SBH resulted in reduced infiltration of lymphocytes (arrow heads) and neutrophils (arrows) and improved histological appearance of the heart and lung tissues

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