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Table 3 Differentially expressed proteins involved in the TCA cycle, fatty acid beta-oxidation, and electron transport chain

From: Maternal diet deficient in riboflavin induces embryonic death associated with alterations in the hepatic proteome of duck embryos

UniProtKB ID Protein description Protein name % coverage Peptides number Unique peptides Fold change* P-Value Co-factor
TCA cycle
 U3IHF6 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 32.23 17 17 −5.17 2.24E-08 FAD
 U3J5X3 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 41.01 11 11 −4.80 5.56E-05  
 U3IR48 Dihydrolipoyl dehydrogenase DLD 42.38 18 18 −4.54 1.91E-05 FAD
 U3J6J0 Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial SUCLG1 36.34 7 7 −2.74 9.55E-03  
 U3INY2 Dihydrolipoamide S-succinyltransferase DLST 31.87 12 12 −1.94 2.55E-02  
 R0L7Q0 Fumarate hydratase FH 59.83 26 26 −1.62 3.80E-03  
 U3I2P1 Isocitrate dehydrogenase [NAD] subunit, mitochondrial IDH3A 28.88 8 8 3.48 6.67E-03  
Fatty acid beta-oxidation
 R0L018 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 46.10 35 35 −5.45 2.10E-14  
 U3INM7 Carnitine palmitoyltransferase 2 CPT2 49.62 33 33 −5.20 5.00E-09  
 U3IR48 Dihydrolipoyl dehydrogenase DLD 42.38 18 18 −4.54 1.91E-05 FAD
 R0LSV8 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial ETFDH 47.37 25 25 −4.33 4.08E-09 FAD
 U3 IU30 Acyl-CoA synthetase long chain family member 1 ACSL1 58.08 43 40 −4.23 1.38E-09  
 U3IAY7 Acyl-CoA dehydrogenase long chain ACADL 50.70 26 26 −3.57 4.72E-08 FAD
 U3J4Z9 Acyl-CoA synthetase long chain family member 5 ACSL5 40.85 24 21 −3.05 7.07E-07  
 U3IFL0 Solute carrier family 25 member 20 SLC25A20 38.01 9 9 −2.90 4.26E-04  
 U3J7F4 Electron transfer flavoprotein alpha subunit ETFA 62.87 17 17 −2.69 1.46E-02 FAD
 U3J8W0 Acyl-CoA dehydrogenase short chain ACADS 49.30 14 14 −2.36 4.32E-03 FAD
 U3IFB0 2,4-dienoyl-CoA reductase 1 DECR1 39.20 9 9 −2.32 2.32E-02  
 U3I806 Trifunctional enzyme subunit alpha, mitochondrial HADHA 53.42 39 38 −2.03 6.79E-03  
 U3IK00 Carnitine palmitoyltransferase 1B CPT1B 17.83 7 7 −1.89 2.53E-03  
 U3J1J0 Acyl-CoA dehydrogenase family member 9 ACAD9 60.22 33 33 −1.73 4.14E-04 FAD
 U3ILK4 Enoyl-CoA delta isomerase 1, mitochondrial ECI1 50.00 11 11 −1.67 1.13E-02  
 U3IHS8 Carnitine O-acetyltransferase CRAT 34.71 22 22 −1.67 8.38E-04  
ETC
 U3IHF6 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 32.23 17 17 −5.17 2.24E-08 FAD
 U3J5X3 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 41.01 11 11 −4.80 5.56E-05  
 R0K082 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 55.59 34 34 −2.79 1.02E-06  
 R0LIL9 ATP synthase subunit O, mitochondrial ATP5PO 69.02 13 13 −2.56 4.03E-03  
 U3IKH0 NADH:ubiquinone oxidoreductase core subunit V2 NDUFV2 64.22 12 12 −2.56 3.46E-02  
 U3 J175 ATP synthase peripheral stalk-membrane subunit b ATP5PB 45.61 15 15 −2.41 4.63E-03  
 U3IK89 ATP synthase F1 subunit gamma ATP5F1C 28.27 15 15 −2.40 4.90E-04  
 U3I5C5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 48.81 16 16 −2.19 2.25E-02 FAD
 U3J3L1 NADH:ubiquinone oxidoreductase core subunit V1 NDUFV1 47.16 11 11 −1.99 9.78E-03 FMN
 U3I8R9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 36.34 11 11 −1.96 5.89E-03 FAD
 U3 J741 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 65.63 7 7 −1.77 4.88E-02  
 U3J1J0 Acyl-CoA dehydrogenase family member 9 ACAD9 60.22 33 33 −1.73 4.14E-04 FAD
 U3I342 Ubiquinol-cytochrome c reductase core protein 2 UQCRC2 61.49 26 26 −1.71 4.82E-03  
 U3IMS0 NADH:ubiquinone oxidoreductase core subunit S3 NDUFS3 55.45 13 13 −1.56 9.70E-03  
  1. TCA tricarboxylic acid, ETC electron transport chain, FMN flavin mononucleotide, FAD flavin adenine dinucleotide
  2. *Fold change is expressed as the ratio of the riboflavin-deficient to the control group. For diminished proteins, the fold change was transformed to the corresponding negative value