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Table 4 Differential metabolites from fetal livers in the top ten enriched KEGG pathways

From: Evidence for liver energy metabolism programming in offspring subjected to intrauterine undernutrition during midgestation

Metabolitea

m/z

rt(s)

VIP

Fold change

P value

Lysine degradation

 N6-Acetyl-L-lysine

189.12

653.67

1.85

1.30

0.022

 L-Lysine

147.11

984.76

4.86

1.19

< 0.000

 L-Pipecolic acid

130.09

984.75

3.83

1.19

< 0.000

 Glutaric acid

131.04

491.25

1.39

0.49

0.046

 DL-2-Aminoadipic acid

162.08

697.23

1.37

1.68

0.066

 Glycine

74.03

704.95

1.19

1.30

0.002

Glycerophospholipid metabolism

 Glycerol 3-phosphate

171.01

816.37

5.92

1.18

0.053

 Glycerophosphocholine

258.11

763.17

1.76

0.65

0.023

 Phosphorylcholine

242.08

732.23

4.08

0.73

0.045

 Acetylcholine

146.12

709.06

5.58

0.82

0.040

 O-Phosphoethanolamine

140.01

864.35

2.45

1.12

0.082

 sn-Glycerol 3-phosphoethanolamine

216.06

740.82

7.13

0.69

0.038

Fructose and mannose metabolism

 Alpha-D-Glucose

179.06

557.54

9.79

1.44

0.012

 D-Sorbitol

181.07

556.12

13.69

0.72

0.014

 D-Mannitol

183.09

551.07

5.18

0.71

0.046

 D-Mannose

198.10

551.23

3.52

1.40

0.032

 Beta-D-Fructose 6-phosphate

259.02

814.70

1.60

0.77

0.018

 DL-lactate

89.03

556.73

1.15

1.24

0.088

Galactose metabolism

 Alpha-D-Glucose

179.06

557.54

9.79

1.44

0.012

 D-Sorbitol

181.07

556.12

13.69

0.72

0.014

 D-Mannose

198.10

551.23

3.52

1.40

0.032

 Glycerol

151.06

187.25

1.08

1.06

0.081

 D-Tagatose

179.06

370.37

1.15

0.65

0.061

Arginine biosynthesis

 L-Glutamine

145.06

699.84

5.05

1.08

0.037

 L-Pyroglutamic acid

130.05

559.43

2.25

1.25

0.007

 L-Citrulline

176.10

731.72

3.45

1.42

0.007

Purine metabolism

 L-Glutamine

145.06

699.84

5.05

1.08

0.037

 Inosine

269.09

306.89

1.26

0.41

0.031

 Hypoxanthine

135.03

304.52

5.86

1.06

0.084

 Adenosine

250.09

186.16

1.65

0.77

0.071

 Adenosine 5′-diphosphate (ADP)

426.02

870.44

1.04

1.19

0.072

 Glycine

74.03

704.95

1.19

1.30

0.002

Primary bile acid biosynthesis

 Taurochenodeoxycholate

498.29

251.31

10.41

1.48

0.047

 Glycine

74.03

704.95

1.19

1.30

0.002

 Taurocholate

516.30

381.79

1.89

0.67

0.067

 Glycocholic acid

483.34

465.40

1.68

0.45

0.022

Histidine metabolism

 1-Methylhistidine

170.09

691.63

2.94

1.34

0.069

 L-Carnosine

227.11

791.19

3.32

0.79

0.012

 L-Histidine

156.08

706.27

3.82

1.26

0.022

 1-Methylhistamine

126.10

624.34

3.19

2.84

0.033

Glycine, serine and threonine metabolism

 DL-Serine

104.04

704.80

6.00

1.29

0.001

 Glycine

74.03

704.95

1.19

1.30

0.002

 L-Threonine

120.07

654.22

2.79

1.14

0.007

Glycolysis/Gluconeogenesis

 alpha-D-Glucose

179.06

557.54

9.79

1.44

0.012

 D-Glucose 6-phosphate

261.04

895.44

4.43

0.67

0.065

 DL-lactate

89.03

556.73

1.15

1.24

0.088

  1. aDifferential metabolites were identified based on the variable importance for a projection (VIP) value > 1, a correlation coefficient between the X variables and a predictive score of predictive component 1 [p (corr)] > 0.6 in the OPLS-DA model and an independent t-test with a significant difference (P < 0.05) and a potential difference (0.05 < P < 0.10). If one differential metabolite was detected in both positive and negative modes, the parameters from positive mode are presented
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Nutrition & Metabolism

ISSN: 1743-7075

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