TY - BOOK AU - Butland, B. AU - Jebb, S. AU - Kopelman, P. AU - McPherson, K. AU - Thomas, S. AU - Mardell, J. PY - 2007 DA - 2007// TI - Tackling obesities:future choices - foresight project report ID - Butland2007 ER - TY - BOOK PY - 2014 DA - 2014// TI - Obesity and overweight. Fact sheet No311 ID - ref2 ER - TY - JOUR AU - Wang, Y. C. AU - McPherson, K. AU - Marsh, T. AU - Gortmaker, S. L. AU - Brown, M. PY - 2011 DA - 2011// TI - Health and economic burden of the projected obesity trends in the USA and the UK JO - Lancet VL - 378 UR - https://doi.org/10.1016/S0140-6736(11)60814-3 DO - 10.1016/S0140-6736(11)60814-3 ID - Wang2011 ER - TY - JOUR AU - Hex, N. AU - Bartlett, C. AU - Wright, D. AU - Taylor, M. AU - Varley, D. PY - 2012 DA - 2012// TI - Estimating the current and future costs of type 1 and type 2 diabetes in the UK, including direct health costs and indirect societal and productivity costs JO - Diabet Med VL - 29 UR - https://doi.org/10.1111/j.1464-5491.2012.03698.x DO - 10.1111/j.1464-5491.2012.03698.x ID - Hex2012 ER - TY - JOUR AU - Jeffery, R. W. AU - Harnack, L. J. PY - 2007 DA - 2007// TI - Evidence implicating eating as a primary driver for the obesity epidemic JO - Diabetes VL - 56 UR - https://doi.org/10.2337/db07-1029 DO - 10.2337/db07-1029 ID - Jeffery2007 ER - TY - JOUR AU - Obici, S. AU - Feng, Z. AU - Karkanias, G. AU - Baskin, D. G. AU - Rossetti, L. PY - 2002 DA - 2002// TI - Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats JO - Nat Neurosci VL - 5 UR - https://doi.org/10.1038/nn0602-861 DO - 10.1038/nn0602-861 ID - Obici2002 ER - TY - JOUR AU - Koch, C. AU - Augustine, R. A. AU - Steger, J. AU - Ganjam, G. K. AU - Benzler, J. AU - Pracht, C. PY - 2010 DA - 2010// TI - Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity JO - J Neurosci VL - 30 UR - https://doi.org/10.1523/JNEUROSCI.3202-10.2010 DO - 10.1523/JNEUROSCI.3202-10.2010 ID - Koch2010 ER - TY - JOUR AU - Thaler, J. P. AU - Yi, C. X. AU - Schur, E. A. AU - Guyenet, S. J. AU - Hwang, B. H. AU - Dietrich, M. O. PY - 2012 DA - 2012// TI - Obesity is associated with hypothalamic injury in rodents and humans JO - J Clin Invest VL - 122 UR - https://doi.org/10.1172/JCI59660 DO - 10.1172/JCI59660 ID - Thaler2012 ER - TY - JOUR AU - Milanski, M. AU - Degasperi, G. AU - Coope, A. AU - Morari, J. AU - Denis, R. AU - Cintra, D. E. PY - 2009 DA - 2009// TI - Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity JO - J Neurosci VL - 29 UR - https://doi.org/10.1523/JNEUROSCI.2760-08.2009 DO - 10.1523/JNEUROSCI.2760-08.2009 ID - Milanski2009 ER - TY - JOUR AU - Tuncman, G. AU - Hirosumi, J. AU - Solinas, G. AU - Chang, L. AU - Karin, M. AU - Hotamisligil, G. S. PY - 2006 DA - 2006// TI - Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance JO - Proc Natl Acad Sci U S A VL - 103 UR - https://doi.org/10.1073/pnas.0603509103 DO - 10.1073/pnas.0603509103 ID - Tuncman2006 ER - TY - JOUR AU - Koch, C. E. AU - Lowe, C. AU - Pretz, D. AU - Steger, J. AU - Williams, L. M. AU - Tups, A. PY - 2014 DA - 2014// TI - High-fat diet induces leptin resistance in leptin-deficient mice JO - J Neuroendocrinol VL - 26 UR - https://doi.org/10.1111/jne.12131 DO - 10.1111/jne.12131 ID - Koch2014 ER - TY - JOUR AU - Cai, D. AU - Liu, T. PY - 2012 DA - 2012// TI - Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB JO - Aging (Albany NY) VL - 4 UR - https://doi.org/10.18632/aging.100431 DO - 10.18632/aging.100431 ID - Cai2012 ER - TY - JOUR AU - Benzler, J. AU - Ganjam, G. K. AU - Legler, K. AU - Stohr, S. AU - Kruger, M. AU - Steger, J. PY - 2013 DA - 2013// TI - Acute inhibition of central c-Jun N-terminal kinase restores hypothalamic insulin signalling and alleviates glucose intolerance in diabetic mice JO - J Neuroendocrinol VL - 25 UR - https://doi.org/10.1111/jne.12018 DO - 10.1111/jne.12018 ID - Benzler2013 ER - TY - JOUR AU - Dalby, M. J. AU - Aviello, G. AU - Ross, A. W. AU - Walker, A. W. AU - Barrett, P. AU - Morgan, P. J. PY - 2018 DA - 2018// TI - Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N JO - Sci Rep VL - 8 UR - https://doi.org/10.1038/s41598-018-33928-4 DO - 10.1038/s41598-018-33928-4 ID - Dalby2018 ER - TY - JOUR AU - Cunarro, J. AU - Casado, S. AU - Lugilde, J. AU - Tovar, S. PY - 2018 DA - 2018// TI - Hypothalamic mitochondrial dysfunction as a target in obesity and metabolic disease JO - Front Endocrinol VL - 9 UR - https://doi.org/10.3389/fendo.2018.00283 DO - 10.3389/fendo.2018.00283 ID - Cunarro2018 ER - TY - JOUR AU - Baufeld, C. AU - Osterloh, A. AU - Prokop, S. AU - Miller, K. R. AU - Heppner, F. L. PY - 2016 DA - 2016// TI - High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia JO - Acta Neuropathol VL - 132 UR - https://doi.org/10.1007/s00401-016-1595-4 DO - 10.1007/s00401-016-1595-4 ID - Baufeld2016 ER - TY - JOUR AU - Gao, Y. AU - Bielohuby, M. AU - Fleming, T. AU - Grabner, G. F. AU - Foppen, E. AU - Bernhard, W. PY - 2017 DA - 2017// TI - Dietary sugars, not lipids, drive hypothalamic inflammation JO - Mol Metab VL - 6 UR - https://doi.org/10.1016/j.molmet.2017.06.008 DO - 10.1016/j.molmet.2017.06.008 ID - Gao2017 ER - TY - BOOK AU - Atkinson, K. E. PY - 1989 DA - 1989// TI - An introduction to numerical analysis ID - Atkinson1989 ER - TY - JOUR AU - McLean, F. H. AU - Grant, C. AU - Morris, A. C. AU - Horgan, G. W. AU - Polanski, A. J. AU - Allan, K. PY - 2018 DA - 2018// TI - Rapid and reversible impairment of episodic memory by a high-fat diet in mice JO - Sci Rep VL - 8 UR - https://doi.org/10.1038/s41598-018-30265-4 DO - 10.1038/s41598-018-30265-4 ID - McLean2018 ER - TY - JOUR AU - Williams, L. M. AU - Campbell, F. M. AU - Drew, J. E. AU - Koch, C. AU - Hoggard, N. AU - Rees, W. D. PY - 2014 DA - 2014// TI - The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phases JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0106159 DO - 10.1371/journal.pone.0106159 ID - Williams2014 ER - TY - JOUR AU - Mayer, C. M. AU - Belsham, D. D. PY - 2010 DA - 2010// TI - Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5′ monophosphate-activated protein kinase activation JO - Endocrinol VL - 151 UR - https://doi.org/10.1210/en.2009-1122 DO - 10.1210/en.2009-1122 ID - Mayer2010 ER - TY - JOUR AU - Cousin, S. P. AU - Hugl, S. R. AU - Wrede, C. E. AU - Kajio, H. AU - Myers, M. G. PY - 2001 DA - 2001// TI - Jr, Rhodes CJ. Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1 JO - Endocrinology VL - 142 UR - https://doi.org/10.1210/endo.142.1.7863 DO - 10.1210/endo.142.1.7863 ID - Cousin2001 ER - TY - STD TI - Sergi D, Morris AC, Kahn DE, McLean FH, Hay EA, Kubitz P, et al. Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4. Nutr Neurosci. 2018:1–14. https://doi.org/10.1080/1028415X.2018.1501533. ID - ref23 ER - TY - JOUR AU - Karpe, F. AU - Dickmann, J. R. AU - Frayn, K. N. PY - 2011 DA - 2011// TI - Fatty acids, obesity, and insulin resistance: time for a reevaluation JO - Diabetes VL - 60 UR - https://doi.org/10.2337/db11-0425 DO - 10.2337/db11-0425 ID - Karpe2011 ER - TY - JOUR AU - Schneider, C. A. AU - Rasband, W. S. AU - Eliceiri, K. W. PY - 2012 DA - 2012// TI - NIH image to ImageJ: 25 years of image analysis JO - Nat Methods VL - 9 UR - https://doi.org/10.1038/nmeth.2089 DO - 10.1038/nmeth.2089 ID - Schneider2012 ER - TY - JOUR AU - Dagda, R. K. AU - Zhu, J. AU - Kulich, S. M. AU - Chu, C. T. PY - 2008 DA - 2008// TI - Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress JO - Autophagy VL - 4 UR - https://doi.org/10.4161/auto.6458 DO - 10.4161/auto.6458 ID - Dagda2008 ER - TY - JOUR AU - Winzell, M. S. AU - Ahren, B. PY - 2004 DA - 2004// TI - The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes JO - Diabetes VL - 53 UR - https://doi.org/10.2337/diabetes.53.suppl_3.S215 DO - 10.2337/diabetes.53.suppl_3.S215 ID - Winzell2004 ER - TY - JOUR AU - Clegg, D. J. AU - Gotoh, K. AU - Kemp, C. AU - Wortman, M. D. AU - Benoit, S. C. AU - Brown, L. M. PY - 2011 DA - 2011// TI - Consumption of a high-fat diet induces central insulin resistance independent of adiposity JO - Physiol Behav VL - 103 UR - https://doi.org/10.1016/j.physbeh.2011.01.010 DO - 10.1016/j.physbeh.2011.01.010 ID - Clegg2011 ER - TY - JOUR AU - Contreras, C. AU - Gonzalez-Garcia, I. AU - Martinez-Sanchez, N. AU - Seoane-Collazo, P. AU - Jacas, J. AU - Morgan, D. A. PY - 2014 DA - 2014// TI - Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance JO - Cell Rep VL - 9 UR - https://doi.org/10.1016/j.celrep.2014.08.057 DO - 10.1016/j.celrep.2014.08.057 ID - Contreras2014 ER - TY - JOUR AU - Zhang, X. AU - Zhang, G. AU - Zhang, H. AU - Karin, M. AU - Bai, H. AU - Cai, D. PY - 2008 DA - 2008// TI - Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity JO - Cell VL - 135 UR - https://doi.org/10.1016/j.cell.2008.07.043 DO - 10.1016/j.cell.2008.07.043 ID - Zhang2008 ER - TY - JOUR AU - Schneeberger, M. AU - Dietrich, M. O. AU - Sebastián, D. AU - Imbernón, M. AU - Castaño, C. AU - Garcia, A. PY - 2013 DA - 2013// TI - Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance JO - Cell VL - 155 UR - https://doi.org/10.1016/j.cell.2013.09.003 DO - 10.1016/j.cell.2013.09.003 ID - Schneeberger2013 ER - TY - JOUR AU - Bae, E. AU - Kim, H. E. AU - Koh, E. AU - Kim, K. PY - 2014 DA - 2014// TI - Phosphoglucomutase1 is necessary for sustained cell growth under repetitive glucose depletion JO - FEBS Lett VL - 588 UR - https://doi.org/10.1016/j.febslet.2014.06.034 DO - 10.1016/j.febslet.2014.06.034 ID - Bae2014 ER - TY - JOUR AU - Minjarez, B. AU - Calderón-González, K. G. AU - Rustarazo, M. L. V. AU - Herrera-Aguirre, M. E. AU - Labra-Barrios, M. L. AU - Rincon-Limas, D. E. PY - 2016 DA - 2016// TI - Identification of proteins that are differentially expressed in brains with Alzheimer's disease using iTRAQ labeling and tandem mass spectrometry JO - J Proteome VL - 139 UR - https://doi.org/10.1016/j.jprot.2016.03.022 DO - 10.1016/j.jprot.2016.03.022 ID - Minjarez2016 ER - TY - JOUR AU - Mamelak, M. PY - 2012 DA - 2012// TI - Sporadic Alzheimer's disease: the starving brain JO - J Alzheimers Dis VL - 31 UR - https://doi.org/10.3233/JAD-2012-120370 DO - 10.3233/JAD-2012-120370 ID - Mamelak2012 ER - TY - JOUR AU - Zahid, S. AU - Oellerich, M. AU - Asif, A. R. AU - Ahmed, N. PY - 2014 DA - 2014// TI - Differential expression of proteins in brain regions of Alzheimer’s disease patients JO - Neurochem Res VL - 39 UR - https://doi.org/10.1007/s11064-013-1210-1 DO - 10.1007/s11064-013-1210-1 ID - Zahid2014 ER - TY - JOUR AU - Perluigi, M. AU - Domenico, F. AU - Giorgi, A. AU - Schinina, M. AU - Coccia, R. AU - Cini, C. PY - 2010 DA - 2010// TI - Redox proteomics in aging rat brain: involvement of mitochondrial reduced glutathione status and mitochondrial protein oxidation in the aging process JO - J Neurosci Res VL - 88 UR - https://doi.org/10.1002/jnr.22500 DO - 10.1002/jnr.22500 ID - Perluigi2010 ER - TY - JOUR AU - Bubber, P. AU - Haroutunian, V. AU - Fisch, G. AU - Blass, J. P. AU - Gibson, G. E. PY - 2005 DA - 2005// TI - Mitochondrial abnormalities in Alzheimer brain: mechanistic implications JO - Ann Neurol VL - 57 UR - https://doi.org/10.1002/ana.20474 DO - 10.1002/ana.20474 ID - Bubber2005 ER - TY - JOUR AU - Fukata, Y. AU - Itoh, T. J. AU - Kimura, T. AU - Menager, C. AU - Nishimura, T. AU - Shiromizu, T. PY - 2002 DA - 2002// TI - CRMP-2 binds to tubulin heterodimers to promote microtubule assembly JO - Nat Cell Biol VL - 4 UR - https://doi.org/10.1038/ncb825 DO - 10.1038/ncb825 ID - Fukata2002 ER - TY - JOUR AU - Jin, X. i. a. o. h. u. a. AU - Sasamoto, K. o. d. a. i. AU - Nagai, J. u. n. AU - Yamazaki, Y. u. k. i. AU - Saito, K. e. n. t. a. AU - Goshima, Y. o. s. h. i. o. AU - Inoue, T. a. k. a. f. u. m. i. AU - Ohshima, T. o. s. h. i. o. PY - 2016 DA - 2016// TI - Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus JO - Neural Plasticity VL - 2016 UR - https://doi.org/10.1155/2016/6790743 DO - 10.1155/2016/6790743 ID - Jin2016 ER - TY - JOUR AU - Williams, L. M. PY - 2012 DA - 2012// TI - Hypothalamic dysfunction in obesity JO - Proc Nutr Soc VL - 71 UR - https://doi.org/10.1017/S002966511200078X DO - 10.1017/S002966511200078X ID - Williams2012 ER - TY - JOUR AU - Matus, A. PY - 2005 DA - 2005// TI - Growth of dendritic spines: a continuing story JO - Curr Opin Neurobiol VL - 15 UR - https://doi.org/10.1016/j.conb.2005.01.015 DO - 10.1016/j.conb.2005.01.015 ID - Matus2005 ER - TY - JOUR AU - Liu, T. AU - Kong, D. AU - Shah, B. P. AU - Ye, C. AU - Koda, S. AU - Saunders, A. PY - 2012 DA - 2012// TI - Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone JO - Neuron VL - 73 UR - https://doi.org/10.1016/j.neuron.2011.11.027 DO - 10.1016/j.neuron.2011.11.027 ID - Liu2012 ER - TY - JOUR AU - Korobova, F. AU - Svitkina, T. PY - 2010 DA - 2010// TI - Molecular architecture of synaptic actin cytoskeleton in hippocampal neurons reveals a mechanism of dendritic spine morphogenesis JO - Mol Biol Cell VL - 21 UR - https://doi.org/10.1091/mbc.e09-07-0596 DO - 10.1091/mbc.e09-07-0596 ID - Korobova2010 ER - TY - JOUR AU - Conde, C. AU - Cáceres, A. PY - 2009 DA - 2009// TI - Microtubule assembly, organization and dynamics in axons and dendrites JO - Nat Rev Neurosci VL - 10 UR - https://doi.org/10.1038/nrn2631 DO - 10.1038/nrn2631 ID - Conde2009 ER - TY - JOUR AU - Cingolani, L. A. AU - Goda, Y. PY - 2008 DA - 2008// TI - Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy JO - Nat Rev Neurosci VL - 9 UR - https://doi.org/10.1038/nrn2373 DO - 10.1038/nrn2373 ID - Cingolani2008 ER - TY - JOUR AU - Kim, I. H. AU - Racz, B. AU - Wang, H. AU - Burianek, L. AU - Weinberg, R. AU - Yasuda, R. PY - 2013 DA - 2013// TI - Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities JO - J Neurosci VL - 33 UR - https://doi.org/10.1523/JNEUROSCI.0035-13.2013 DO - 10.1523/JNEUROSCI.0035-13.2013 ID - Kim2013 ER - TY - JOUR AU - Ginguay, A. AU - Cynober, L. AU - Curis, E. AU - Nicolis, I. PY - 2017 DA - 2017// TI - Ornithine aminotransferase, an important glutamate-metabolizing enzyme at the crossroads of multiple metabolic pathways JO - Biology VL - 6 UR - https://doi.org/10.3390/biology6010018 DO - 10.3390/biology6010018 ID - Ginguay2017 ER - TY - JOUR AU - Wong, P. AU - McGeer, E. AU - McGeer, P. PY - 1981 DA - 1981// TI - A sensitive radiometric assay for ornithine aminotransferase: regional and subcellular distributions in rat brain JO - J Neurochem VL - 36 UR - https://doi.org/10.1111/j.1471-4159.1981.tb01620.x DO - 10.1111/j.1471-4159.1981.tb01620.x ID - Wong1981 ER - TY - JOUR AU - Horvath, T. L. AU - Sarman, B. AU - Garcia-Caceres, C. AU - Enriori, P. J. AU - Sotonyi, P. AU - Shanabrough, M. PY - 2010 DA - 2010// TI - Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity JO - Proc Natl Acad Sci U S A VL - 107 UR - https://doi.org/10.1073/pnas.1004282107 DO - 10.1073/pnas.1004282107 ID - Horvath2010 ER - TY - JOUR AU - Awad, N. AU - Gagnon, M. AU - Messier, C. PY - 2004 DA - 2004// TI - The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function JO - J Clin Exp Neuropsychol VL - 26 UR - https://doi.org/10.1080/13803390490514875 DO - 10.1080/13803390490514875 ID - Awad2004 ER - TY - JOUR AU - Wong, R. H. AU - Scholey, A. AU - Howe, P. R. PY - 2014 DA - 2014// TI - Assessing premorbid cognitive ability in adults with type 2 diabetes mellitus--a review with implications for future intervention studies JO - Curr Diab Rep VL - 14 UR - https://doi.org/10.1007/s11892-014-0547-4 DO - 10.1007/s11892-014-0547-4 ID - Wong2014 ER - TY - JOUR AU - Angelova, P. l. a. m. e. n. a. R. AU - Abramov, A. n. d. r. e. y. Y. PY - 2018 DA - 2018// TI - Role of mitochondrial ROS in the brain: from physiology to neurodegeneration JO - FEBS Letters VL - 592 UR - https://doi.org/10.1002/1873-3468.12964 DO - 10.1002/1873-3468.12964 ID - Angelova2018 ER - TY - JOUR AU - Zhang, X. AU - Dong, F. AU - Ren, J. AU - Driscoll, M. J. AU - Culver, B. PY - 2005 DA - 2005// TI - High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex JO - Exp Neurol VL - 191 UR - https://doi.org/10.1016/j.expneurol.2004.10.011 DO - 10.1016/j.expneurol.2004.10.011 ID - Zhang2005 ER -