Fig. 3

Effect of 16-week PY diet on hepatic lipid profiles. Hepatic lipid levels (a). Lipid-regulating enzyme activities (b). Lipid-metabolism related genes (c). Morphology (d). Data are mean ± S.E. Significant differences between HFD versus ND are indicated; ^*p < 0.05, ^**p < 0.01, ^***p < 0.001. Significant differences between HFD versus PY are indicated; ^$p < 0.05, ^$$p < 0.01, ^$$$p < 0.001. ND, normal diet (AIN-76, 5% fat, w/w); HFD, high-fat diet (20% fat, 1% cholesterol, w/w); PY, HFD + 0.002% physcion (w/w); ME, malic enzyme; FASN, fatty acid synthase; PPAR γ, peroxisome proliferator-activated receptor gamma; SREBP-1a and 1c, sterol regulatory element binding protein 1a and 1c; ACC1, acetyl-CoA carboxylase 1; SCD1, stearoyl-CoA desaturase 1; PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1-alpha; CPT1, carnitine palmitoyl-CoA transferase 1. Hematoxylin and Eosin (H&E) stained transverse-section of liver. Representative photomicrographs of liver are shown at 200x