Fig. 1

A flowchart of competing endogenous RNAs (ceRNAs) network construction. (1) DEGs and DELs with fold change ≥2.0 and adjust P-value < 0.05 were used, whereas DEMis was used with fold change ≥1.2 and adjust P-value < 0.05; (2) mRNAs-miRNAs interactions were predicted by miRbase and TargetScan databases; (3) miRNA-lncRNA interactions were predicted by miRcode and starBase databases; (4) lncRNAs which were not associated with DEMis were removed; (5) mRNAs that were not matched DEMis were removed; (6) ceRNA network was constructed