Fig. 2

Locomotor activity and oxygen consumption in each mouse group. a Locomotor activity of 18-week-old wild-type (WT; HFD, n = 6) and Ccr7 null (KO; HFD, n = 6) mice. Total traveled distance (day, 8 a.m. to 8 p.m.; night, 8 p.m. to 8 a.m.) was analyzed using the ANY-maze video tracking system. b In 19-week-old WT (HFD, n = 6) and KO (HFD, n = 6) mice, oxygen consumption (VO₂) and carbon dioxide production (VCO₂) were assessed by an indirect calorimetric system over a 24-h period with a 12-h light/dark cycle (day from 8 a.m. to 8 p.m.); the respiratory exchange ratio (RER) c and energy expenditure d are shown. Data are presented as means ± S.E. ***, p < 0.001 versus the corresponding WT value