Table 1 Metabolic parameters in serum and tissues in HHTg rats and after methylglyoxal administration (HHTg + MGO)
HHTg | HHTg + MGO | P< | |
|---|---|---|---|
Body weight (g) | 412 ± 3 | 397 ± 6 | n.s. |
Glucose (mmol/l) | 7.1 ± 0.2 | 8.8 ± 0.2 | 0.001 |
Insulin (μmol/l) | 0.25 ± 0.03 | 0.52 ± 0.03 | 0.05 |
AUC0–120 mmol/l | 930 ± 26 | 1006 ± 18 | 0.05 |
FFA (mmol/l) | 0.43 ± 0.05 | 0.49 ± 0.06 | n.s. |
Adiponectin (μg/ml) | 2.90 ± 0.34 | 2.78 ± 0.51 | n.s. |
Serum triglycerides (mmol/l) | 4.80 ± 0.49 | 3.21 ± 0.51 | 0.05 |
Serum cholesterol (mmol/l) | 1.19 ± 0.07 | 1.56 ± 0.99 | 0.05 |
HDL-C (mmol/l) | 0.59 ± 0.03 | 1.06 ± 0.14 | 0.05 |
Triglycerides in the liver (μmol/g) | 13.01 ± 1.58 | 13.02 ± 0.94 | n.s. |
Triglycerides in the kidney (μmol/g) | 8.55 ± 1.61 | 6.81 ± 1.16 | n.s. |
Methylglyoxal in serum (nmol/ml) | 0.24 ± 0.02 | 0.37 ± 0.02 | 0.01 |
Methylglyoxal in the kidney (nmol/mg) | 0.59 ± 0.08 | 0.86 ± 0.09 | 0.01 |
Methylglyoxal in the liver (nmol/mg) | 1.62 ± 0.12 | 5.26 ± 0.58 | 0.001 |