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Fig. 5 | Nutrition & Metabolism

Fig. 5

From: Dietary curcumin enhances insulin clearance in diet-induced obese mice via regulation of hepatic PI3K-AKT axis and IDE, and preservation of islet integrity

Fig. 5

CUR administration decreases TXNIP expression. a At the end of the study, pancreas sections from Control, HFS, and HFS + CUR diet mice were DAB stained for TXNIP and quantified using ImageJ software. b and c Islets from C57Bl/6 J mice or human donors were cultured for 24 h under high glucose (20 mM) or high glucose plus palmitate (500 mM) conditions in the presence or absence of CUR (1 nM). TXNIP mRNA expression was determined by RT-PCR and normalized to 18S. (**p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001 compared to each other)

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