Fig. 2From: Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecologyEffects of fucoidan on the levels of cytokines and Tregs in spleen in NOD mice. a levels of cytokines in spleen. After intervention with 300 mg/kg.BW and 600 mg/kg.BW fucoidan for 5 weeks, the levels of Th1 type cytokines, IL-1, IL-2, IL-6 and IFN-γ in the spleen of 12-week-old NOD mice were lower than those in the control group. But the levels of Th2 anti-inflammatory cytokines, IL-4, IL-10 and TGF-β were significantly elevated, especially in the high dose fucoidan group. b CD4 + CD25 + Foxp3 + Tregs were detected by flow cytometry. Fucoidan intervention could significantly promote the differentiation of CD4 + CD25 + Foxp3 + Treg in spleen lymphocytes. *, Compared with the control group, P < 0.05; **, Compared with the control group, P < 0.01; #, Compared with the 300 mg/kg.BW fucoidan intervention group, P < 0.05Back to article page