Skip to main content
Fig. 3 | Nutrition & Metabolism

Fig. 3

From: Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology

Fig. 3

Effects of fucoidan on Foxp3 expression in spleen and DC phenotype in NOD mice. a Western Blot analysis of Foxp3 expression in spleen. Fucoidan intervention up-regulated spleen Foxp3 levels. b Effect of fucoidan on DC phenotype in NOD mice. Flow cytometry was used to analyze the expression of MHC-II and costimulatory molecule CD86 on DC surface. The expressions of MHC II and CD86 in CD11c + DCs in the 12-week-old NOD mice in the fucoidan intervention group was significantly lower than those in the control group. Especially in the high-dose fucoidan group, the effect was more pronounced. The expressions of MHC II and CD86 in CD11c + DCs in the 12-week-old NOD mice in the fucoidan intervention group was significantly lower than those in the control group. *, Compared with the control group, P < 0.05; **, Compared with the control group, P < 0.01; #, Compared with the 300 mg/kg.BW fucoidan intervention group, P < 0.05

Back to article page