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Fig. 6 | Nutrition & Metabolism

Fig. 6

From: Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology

Fig. 6

Alpha diversity analysis and Beta diversity analysis in gut flora of NOD mice. a Alpha diversity analysis in gut flora of NOD mice. There was no significant difference in the Chao1 index, observed_species index, Shannon index and Simpson index between the NOD control group and the 600 mg / kg. BW fucoidan intervention group. b Venn diagram of bacterial OTU; c PCA analysis based on OTU abundance; d Anosim analysis map; e beta diversity heat map. In the Venn, the number of OTUs hold in common in the NOD control group and the 600 mg/kg.BW fucoidan intervention group was 351. The number of unique OTUs is 57 and 75 respectively. According to PCA analysis, there was a difference in microbial composition between the two groups. Based on weighted Unifrac clustering beta diversity analysis (Anosim), the results showed that the composition of the gut flora in the two groups was significantly different (R = 0.369, P = 0.001). At the OTU level, there was a significant difference in the gut flora structure between the control group and the fucoidan intervention group. A2: NOD control group C2: 600 mg/kg. BW fucoidan intervention group

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Nutrition & Metabolism

ISSN: 1743-7075

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