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Table 1 Baseline characteristics of individuals stratified into three tertiles by weighted T2D-GRS

From: Alcohol consumption and its interaction with genetic variants are strongly associated with the risk of type 2 diabetes: a prospective cohort study

Variables   Weighted type 2 diabetes GRS P value
Overall (n = 2546) Low (n = 848) Intermediate (n = 849) High (n = 849)
Age (years) 54.17 ± 14.73 54.25 ± 14.99 54.46 ± 14.26 53.79 ± 14.93 0.6335
BMI (kg/m2) 24.94 ± 3.46 23.92 ± 3.40 24.08 ± 3.56 23.83 ± 3.43 0.3491
Man (n, %) 1029 (47.49) 356 (41.98) 332 (39.1) 341 (40.16) 0.4745
Smoking (n, %) 494 (22.85) 176 (24.55) 144 (19.81) 174 (24.23) 0.0559
Drinking (n, %) 1538 (71.2) 519 (72.49) 514 (70.7) 505 (70.43) 0.6467
Sugar intake (n, %) 1199 (52.91) 396 (53.23) 384 (50) 419 (55.57) 0.0915
Fasting plasma glucose (mmol/l) 4.97 ± 0.53 4.91 ± 0.50 4.98 ± 0.55 5.01 ± 0.54 0.0006
2 h plasma glucose (mmol/l) 5.68 ± 1.62 5.63 ± 1.53 5.68 ± 1.63 5.74 ± 1.70 0.3922
Fasting insulin (mU/l) 6.97 (4.62, 10.04) 6.82 (4.62, 9.91) 7.19 (4.69, 10.12) 6.95 (4.57, 10.12) 0.2754
2 h insulin (mU/l) 39.12 (24.09, 59.86) 39.59 (24.69, 59.86) 39.11 (24.20, 58.97) 38.70 (23.72, 60.93) 0.9809
HOMA-IR 1.53 (0.99, 2.26) 1.48 (0.97, 2.20) 1.56 (1.00, 2.35) 1.56 (1.01, 2.29) 0.1602
HOMA-B 99.55 (67.54, 144.76) 100.95 (69.44, 145.37) 101.69 (68.63, 146.91) 97.04 (63.38, 141.82) 0.1585
Incident cases (n) 611 168 207 236 0.0012
  1. Low: weighted T2D-GRS < 43.0; Intermediate: 43.0 ≤ weighted T2D-GRS < 46.7; High: weighted T2D-GRS ≥ 46.7
  2. Data are shown as the mean ± SD, median (interquartile range) or n (%)
  3. Comparisons were done using ANOVA test