|
Variables
| |
Weighted type 2 diabetes GRS
|
P value
|
|---|
|
Overall (n = 2546)
|
Low (n = 848)
|
Intermediate (n = 849)
|
High (n = 849)
|
|---|
|
Age (years)
|
54.17 ± 14.73
|
54.25 ± 14.99
|
54.46 ± 14.26
|
53.79 ± 14.93
|
0.6335
|
|
BMI (kg/m2)
|
24.94 ± 3.46
|
23.92 ± 3.40
|
24.08 ± 3.56
|
23.83 ± 3.43
|
0.3491
|
|
Man (n, %)
|
1029 (47.49)
|
356 (41.98)
|
332 (39.1)
|
341 (40.16)
|
0.4745
|
|
Smoking (n, %)
|
494 (22.85)
|
176 (24.55)
|
144 (19.81)
|
174 (24.23)
|
0.0559
|
|
Drinking (n, %)
|
1538 (71.2)
|
519 (72.49)
|
514 (70.7)
|
505 (70.43)
|
0.6467
|
|
Sugar intake (n, %)
|
1199 (52.91)
|
396 (53.23)
|
384 (50)
|
419 (55.57)
|
0.0915
|
|
Fasting plasma glucose (mmol/l)
|
4.97 ± 0.53
|
4.91 ± 0.50
|
4.98 ± 0.55
|
5.01 ± 0.54
|
0.0006
|
|
2 h plasma glucose (mmol/l)
|
5.68 ± 1.62
|
5.63 ± 1.53
|
5.68 ± 1.63
|
5.74 ± 1.70
|
0.3922
|
|
Fasting insulin (mU/l)
|
6.97 (4.62, 10.04)
|
6.82 (4.62, 9.91)
|
7.19 (4.69, 10.12)
|
6.95 (4.57, 10.12)
|
0.2754
|
|
2 h insulin (mU/l)
|
39.12 (24.09, 59.86)
|
39.59 (24.69, 59.86)
|
39.11 (24.20, 58.97)
|
38.70 (23.72, 60.93)
|
0.9809
|
|
HOMA-IR
|
1.53 (0.99, 2.26)
|
1.48 (0.97, 2.20)
|
1.56 (1.00, 2.35)
|
1.56 (1.01, 2.29)
|
0.1602
|
|
HOMA-B
|
99.55 (67.54, 144.76)
|
100.95 (69.44, 145.37)
|
101.69 (68.63, 146.91)
|
97.04 (63.38, 141.82)
|
0.1585
|
|
Incident cases (n)
|
611
|
168
|
207
|
236
|
0.0012
|
- Low: weighted T2D-GRS < 43.0; Intermediate: 43.0 ≤ weighted T2D-GRS < 46.7; High: weighted T2D-GRS ≥ 46.7
- Data are shown as the mean ± SD, median (interquartile range) or n (%)
- Comparisons were done using ANOVA test
