Table 1 Baseline characteristics of individuals stratified into three tertiles by weighted T2D-GRS
Variables | Weighted type 2 diabetes GRS | P value | |||
|---|---|---|---|---|---|
Overall (n = 2546) | Low (n = 848) | Intermediate (n = 849) | High (n = 849) | ||
Age (years) | 54.17 ± 14.73 | 54.25 ± 14.99 | 54.46 ± 14.26 | 53.79 ± 14.93 | 0.6335 |
BMI (kg/m2) | 24.94 ± 3.46 | 23.92 ± 3.40 | 24.08 ± 3.56 | 23.83 ± 3.43 | 0.3491 |
Man (n, %) | 1029 (47.49) | 356 (41.98) | 332 (39.1) | 341 (40.16) | 0.4745 |
Smoking (n, %) | 494 (22.85) | 176 (24.55) | 144 (19.81) | 174 (24.23) | 0.0559 |
Drinking (n, %) | 1538 (71.2) | 519 (72.49) | 514 (70.7) | 505 (70.43) | 0.6467 |
Sugar intake (n, %) | 1199 (52.91) | 396 (53.23) | 384 (50) | 419 (55.57) | 0.0915 |
Fasting plasma glucose (mmol/l) | 4.97 ± 0.53 | 4.91 ± 0.50 | 4.98 ± 0.55 | 5.01 ± 0.54 | 0.0006 |
2 h plasma glucose (mmol/l) | 5.68 ± 1.62 | 5.63 ± 1.53 | 5.68 ± 1.63 | 5.74 ± 1.70 | 0.3922 |
Fasting insulin (mU/l) | 6.97 (4.62, 10.04) | 6.82 (4.62, 9.91) | 7.19 (4.69, 10.12) | 6.95 (4.57, 10.12) | 0.2754 |
2 h insulin (mU/l) | 39.12 (24.09, 59.86) | 39.59 (24.69, 59.86) | 39.11 (24.20, 58.97) | 38.70 (23.72, 60.93) | 0.9809 |
HOMA-IR | 1.53 (0.99, 2.26) | 1.48 (0.97, 2.20) | 1.56 (1.00, 2.35) | 1.56 (1.01, 2.29) | 0.1602 |
HOMA-B | 99.55 (67.54, 144.76) | 100.95 (69.44, 145.37) | 101.69 (68.63, 146.91) | 97.04 (63.38, 141.82) | 0.1585 |
Incident cases (n) | 611 | 168 | 207 | 236 | 0.0012 |