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Table 2 Relative risk and 95% confidence interval for the 5-year incidence of type 2 diabetes according to LAP trajectories and baseline LAP

From: Association of lipid accumulation product trajectories with 5-year incidence of type 2 diabetes in Chinese adults: a cohort study

Variables N Cases (%) Model 1a
Adjusted
RR (95% CI)
Model 2b
Adjusted
RR (95% CI)
Model 3c
Adjusted
RR (95% CI)
LAP trajectories 4508 169 (3.8)    
 Trajectory 1: low 3639 78 (2.1) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
 Trajectory 2: moderate 800 80 (10.0) 3.51 (2.57–4.80) 2.56 (1.78–3.70) 1.95 (1.41–2.70)
 Trajectory 3: high 69 11 (15.9) 7.68 (4.12–14.32) 5.20 (2.77–9.76) 2.20 (1.12–4.30)
P value for trend    < 0.001 < 0.001 < 0.001
Baseline LAP (groups)d 4179 154 (3.7)    
 First group: (< 42.4) 3368 69 (2.1) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
 Second group: (42.4 ≤ ~ < 121.6) 748 78 (10.4) 3.60 (2.61–4.96) 2.56 (1.76–3.73) 1.73 (1.25–2.38)
 Third group: (≥121.6) 63 7 (11.1) 4.62 (2.21–9.66) 2.61 (1.15–5.95) 1.47 (0.66–3.31)
P value for trend    < 0.001 < 0.001 0.006
Baseline LAP (tertiles) 4179 154 (3.7)    
 First tertile: (< 12.7) 1393 12 (0.9) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
 Second tertile: (12.7 ≤ ~ < 29.3) 1394 27 (1.9) 1.33 (0.67–2.66) 1.04 (0.52–2.07) 1.03 (0.52–2.03)
 Third tertile: (≥29.3) 1392 115 (8.3) 4.90 (2.65–9.06) 2.93 (1.52–5.65) 1.91 (0.97–3.74)
P value for trend    < 0.001 < 0.001 0.007
  1. LAP lipid accumulation product
  2. aModel 1: adjusted for baseline age, gender, race, current smoking, current alcohol drinking, and married status
  3. bModel 2: further adjusted for baseline diagnosis of hypertension, use of antihypertensive, total cholesterol, high-density lipoprotein cholesterol, hemoglobin, creatinine, and uric acid
  4. cModel 3: further adjusted for baseline blood glucose and family history of diabetes
  5. dFrom first to the third group, the proportions of subjects were 80.6, 17.9, and 1.5%, respectively. The divisions were consistent with the proportions of different LAP trajectories