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Table 2 Relative risk and 95% confidence interval for the 5-year incidence of type 2 diabetes according to LAP trajectories and baseline LAP

From: Association of lipid accumulation product trajectories with 5-year incidence of type 2 diabetes in Chinese adults: a cohort study

Variables

N

Cases (%)

Model 1a

Adjusted

RR (95% CI)

Model 2b

Adjusted

RR (95% CI)

Model 3c

Adjusted

RR (95% CI)

LAP trajectories

4508

169 (3.8)

   

 Trajectory 1: low

3639

78 (2.1)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

 Trajectory 2: moderate

800

80 (10.0)

3.51 (2.57–4.80)

2.56 (1.78–3.70)

1.95 (1.41–2.70)

 Trajectory 3: high

69

11 (15.9)

7.68 (4.12–14.32)

5.20 (2.77–9.76)

2.20 (1.12–4.30)

P value for trend

  

< 0.001

< 0.001

< 0.001

Baseline LAP (groups)d

4179

154 (3.7)

   

 First group: (< 42.4)

3368

69 (2.1)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

 Second group: (42.4 ≤ ~ < 121.6)

748

78 (10.4)

3.60 (2.61–4.96)

2.56 (1.76–3.73)

1.73 (1.25–2.38)

 Third group: (≥121.6)

63

7 (11.1)

4.62 (2.21–9.66)

2.61 (1.15–5.95)

1.47 (0.66–3.31)

P value for trend

  

< 0.001

< 0.001

0.006

Baseline LAP (tertiles)

4179

154 (3.7)

   

 First tertile: (< 12.7)

1393

12 (0.9)

1.00 (Ref)

1.00 (Ref)

1.00 (Ref)

 Second tertile: (12.7 ≤ ~ < 29.3)

1394

27 (1.9)

1.33 (0.67–2.66)

1.04 (0.52–2.07)

1.03 (0.52–2.03)

 Third tertile: (≥29.3)

1392

115 (8.3)

4.90 (2.65–9.06)

2.93 (1.52–5.65)

1.91 (0.97–3.74)

P value for trend

  

< 0.001

< 0.001

0.007

  1. LAP lipid accumulation product
  2. aModel 1: adjusted for baseline age, gender, race, current smoking, current alcohol drinking, and married status
  3. bModel 2: further adjusted for baseline diagnosis of hypertension, use of antihypertensive, total cholesterol, high-density lipoprotein cholesterol, hemoglobin, creatinine, and uric acid
  4. cModel 3: further adjusted for baseline blood glucose and family history of diabetes
  5. dFrom first to the third group, the proportions of subjects were 80.6, 17.9, and 1.5%, respectively. The divisions were consistent with the proportions of different LAP trajectories