Fig. 4

Hepatic-PKA inhibition exacerbated HFD induced lipid accumulation in liver on an early stage. Mice were fed with high fat diet (HFD) from 8-week old for 2 months. a The body weight of PKAi and control mice. b The ratio of liver weight to body weight of PKAi and control mice. c The concentration of triglyceride of the livers. d-e The representative images of H&E staining (d) and oil red staining (e) of liver tissue. Scale bar: 50 μm. *p < 0.05, **p < 0.01 vs control by t-test. (N = 6)