Subcutaneous fat mass is associated with genetic risk scores related to proinflammatory cytokine signaling and interact with physical activity in middle-aged obese adults

Table 3 The characteristics of the ten genetic variants used for the generalized multifactor dimensionality reduction analysis

CHR¹	SNP	Position²	Minor	Major	OR³	P_adjust⁴	MAF⁵	HWE⁶	GENE	Function
1	rs4846514	214,769,308	G	A	1.171	0.037	0.198	0.093	ESRRG	Intron variant
1	rs7526590	91,994,042	T	A	1.287	0.0002	0.291	0.122	TGFBR3	Intron variant
3	rs2290610	3,114,957	C	T	0.817	0.002	0.359	0.212	IL5RA	Missense variant
3	rs3792421	3,124,791	G	A	0.831	0.004	0.357	0.158	IL5RA	Intron variant
3	rs17024684	3,030,247	A	G	1.269	0.012	0.115	0.294	CNTN4	Intron variant
5	rs326149	7,865,445	G	T	1.283	0.0009	0.193	0.060	ADCY2	Intron variant
5	rs733730	156,665,645	T	C	0.862	0.034	0.260	0.782	CYFIP2	Intron variant
6	rs4711998	52,158,312	G	A	0.81 7	0.004	0.277	0.426	IL17A	Upstream transcript variant
10	rs7917983	114,722,872	T	C	0.792	0.002	0.213	0.281	TCF7L2	Upstream transcript variant
19	rs41497444	57,476,717	C	A	0.787	0.001	0.245	0.070	ZNF766	Upstream transcript variant

ESRRG estrogen related receptor gamma, TGFBR3 transforming growth factor beta receptor 3, IL5RA interleukin 5 receptor subunit alpha, CNTN4 contactin 4, ADCY2 adenylate cyclase 2. CYFIP2 cytoplasmic FMR1 interacting protein 2, IL17A interleukin 17A, TCF7L2 transcription factor 7 like 2, ZNF766 zinc finger protein 766
¹The chromosome number of the gene SNP. ²The position of SNP in the chromosome. ³Odds ratio (OR) to influence subcutaneous fat thickness at subscapular site from GWAS analysis. ⁴P value for OR of the minor alleles of the SNP in GWAS analysis with adjusted for covariates of age, gender, residence area, and BMI. ⁵Minor allele frequency (MAF). ⁶P value for Hardy–Weinberg equilibrium (HWE)

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