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Table 3 The characteristics of the ten genetic variants used for the generalized multifactor dimensionality reduction analysis

From: Subcutaneous fat mass is associated with genetic risk scores related to proinflammatory cytokine signaling and interact with physical activity in middle-aged obese adults

CHR1SNPPosition2MinorMajorOR3P_adjust4MAF5HWE6GENEFunction
1rs4846514214,769,308GA1.1710.0370.1980.093ESRRGIntron variant
1rs752659091,994,042TA1.2870.00020.2910.122TGFBR3Intron variant
3rs22906103,114,957CT0.8170.0020.3590.212IL5RAMissense variant
3rs37924213,124,791GA0.8310.0040.3570.158IL5RAIntron variant
3rs170246843,030,247AG1.2690.0120.1150.294CNTN4Intron variant
5rs3261497,865,445GT1.2830.00090.1930.060ADCY2Intron variant
5rs733730156,665,645TC0.8620.0340.2600.782CYFIP2Intron variant
6rs471199852,158,312GA0.81 70.0040.2770.426IL17AUpstream transcript variant
10rs7917983114,722,872TC0.7920.0020.2130.281TCF7L2Upstream transcript variant
19rs4149744457,476,717CA0.7870.0010.2450.070ZNF766Upstream transcript variant
  1. ESRRG estrogen related receptor gamma, TGFBR3 transforming growth factor beta receptor 3, IL5RA interleukin 5 receptor subunit alpha, CNTN4 contactin 4, ADCY2 adenylate cyclase 2. CYFIP2 cytoplasmic FMR1 interacting protein 2, IL17A interleukin 17A, TCF7L2 transcription factor 7 like 2, ZNF766 zinc finger protein 766
  2. 1The chromosome number of the gene SNP. 2The position of SNP in the chromosome. 3Odds ratio (OR) to influence subcutaneous fat thickness at subscapular site from GWAS analysis. 4P value for OR of the minor alleles of the SNP in GWAS analysis with adjusted for covariates of age, gender, residence area, and BMI. 5Minor allele frequency (MAF). 6P value for Hardy–Weinberg equilibrium (HWE)