Skip to main content

Table 3 The characteristics of the ten genetic variants used for the generalized multifactor dimensionality reduction analysis

From: Subcutaneous fat mass is associated with genetic risk scores related to proinflammatory cytokine signaling and interact with physical activity in middle-aged obese adults

CHR1

SNP

Position2

Minor

Major

OR3

P_adjust4

MAF5

HWE6

GENE

Function

1

rs4846514

214,769,308

G

A

1.171

0.037

0.198

0.093

ESRRG

Intron variant

1

rs7526590

91,994,042

T

A

1.287

0.0002

0.291

0.122

TGFBR3

Intron variant

3

rs2290610

3,114,957

C

T

0.817

0.002

0.359

0.212

IL5RA

Missense variant

3

rs3792421

3,124,791

G

A

0.831

0.004

0.357

0.158

IL5RA

Intron variant

3

rs17024684

3,030,247

A

G

1.269

0.012

0.115

0.294

CNTN4

Intron variant

5

rs326149

7,865,445

G

T

1.283

0.0009

0.193

0.060

ADCY2

Intron variant

5

rs733730

156,665,645

T

C

0.862

0.034

0.260

0.782

CYFIP2

Intron variant

6

rs4711998

52,158,312

G

A

0.81 7

0.004

0.277

0.426

IL17A

Upstream transcript variant

10

rs7917983

114,722,872

T

C

0.792

0.002

0.213

0.281

TCF7L2

Upstream transcript variant

19

rs41497444

57,476,717

C

A

0.787

0.001

0.245

0.070

ZNF766

Upstream transcript variant

  1. ESRRG estrogen related receptor gamma, TGFBR3 transforming growth factor beta receptor 3, IL5RA interleukin 5 receptor subunit alpha, CNTN4 contactin 4, ADCY2 adenylate cyclase 2. CYFIP2 cytoplasmic FMR1 interacting protein 2, IL17A interleukin 17A, TCF7L2 transcription factor 7 like 2, ZNF766 zinc finger protein 766
  2. 1The chromosome number of the gene SNP. 2The position of SNP in the chromosome. 3Odds ratio (OR) to influence subcutaneous fat thickness at subscapular site from GWAS analysis. 4P value for OR of the minor alleles of the SNP in GWAS analysis with adjusted for covariates of age, gender, residence area, and BMI. 5Minor allele frequency (MAF). 6P value for Hardy–Weinberg equilibrium (HWE)