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Table 5 Adjusted odds ratios for metabolic disease risk factors according to the genetic risk scores (GRS) of model 7 for subcutaneous fat deposition

From: Subcutaneous fat mass is associated with genetic risk scores related to proinflammatory cytokine signaling and interact with physical activity in middle-aged obese adults

 Model 1Model 2
Low-GRS
(n = 999)
Medium-GRS
(n = 1551)
High-GRS
(n = 744)
Medium-GRS
(n = 1551)
High-GRS
(n = 744)
Subcutaneous fat (mm)11.703 (1.385~2.093)***2.317 (1.826~2.940)***1.697 (1.334~2.159)***2.232 (1.676~2.972)***
Waist circumference (cm)10.990 (0.801~1.222)1.046 (0.813~1.347)1.128 (0.869~1.465)1.105 (0.803~1.522)
Serum total cholesterol (mg/dl)11.220 (0.981~1.517)1.152 (0.889~1.494)1.289 (0.998~1.665)1.087 (0.795~1.488)
Serum HDL (mg/dl)10.804 (0.683~0.948)**0.709 (0.581~0.864)**0.841 (0.688~1.029)0.827 (0.646~1.057)
Serum LDL (mg/dl)10.983 (0.790~1.224)1.011 (0.780~1.312)1.047 (0.807~1.359)1.051 (0.768~1.438)
Serum TG (mg/dl)10.878 (0.735~1.049)0.986 (0.799~1.217)0.960 (0.774~1.192)1.036 (0.798~1.345)
Plasma glucose (mg/dL)10.994 (0.676~1.463)0.933 (0.584~1.490)0.952 (0.615~1.473)0.935 (0.549~1.595)
Serum CRP-1 (mg/dL)11.321 (0.984~1.790)1.218 (0.886~1.677)1.384 (0.972~2.008)1.440 (0.977~2.123)
  1. HDL high density lipoprotein cholesterol, LDL low-density lipoprotein cholesterol, TG triglyceride, CRP-1 C-reactive protein
  2. Values represent odd ratios and 95% confidence intervals
  3. GRS was divided into 3 categories by tertiles of GRS in the model which included IL17A rs4711998, ADCY2 rs326149, ESRRG rs4846514, CYFIP2 rs733730, TCF7L2 rs7917983, ZNF766 rs41497444 and TGFBR3 rs7526590
  4. Low-GRS was the reference for both model 1 and model 2
  5. **Significantly different from low GRS in logistic regression analysis at P < 0.01, *** P < 0.001
  6. Model 1: Adjusted for age, gender, residence area, and BMI
  7. Model 2: Adjusted for age, gender, residence area, BMI, waist circumference, hip circumference, body fat, alcohol and coffee intake, physical activity, smoking status, and energy intake