Target gene | HP diet | LP diet | HPR diet | p-value |
---|---|---|---|---|
Glucose transport | ||||
glut2a | 0.53 ± 0.21a | 1.20 ± 0.16b | 0.42 ± 0.26a | <0.001 |
glut2b | 0.71 ± 0.19 | 0.85 ± 0.24 | 0.60 ± 0.21 | 0.056 |
glut4a | 0.90 ± 0.15 | 0.99 ± 0.20 | 0.95 ± 0.42 | 0.778 |
glut4b | 0.94 ± 0.21 | 1.13 ± 0.18 | 0.91 ± 0.48 | 0.321 |
Glycolysis | ||||
hk1 | 0.88 ± 0.27 | 0.73 ± 0.13 | 1.13 ± 0.51 | 0.060 |
hk2 | 1.38 ± 0.37 | 1.17 ± 0.24 | 1.47 ± 0.67 | 0.386 |
pkmaa | 0.80 ± 0.37 | 0.85 ± 0.21 | 1.08 ± 0.38 | 0.192 |
pkmab | 0.96 ± 0.17ab | 1.10 ± 0.14b | 0.81 ± 0.25a | 0.015 |
pkmba | 0.83 ± 0.13ab | 0.97 ± 0.20b | 0.69 ± 0.24a | 0.023 |
pkmbb | 0.75 ± 0.15 | 0.87 ± 0.23 | 0.76 ± 0.39 | 0.601 |
gcka | 0.09 ± 0.09a | 2.94 ± 1.42b | 0.03 ± 0.01a | <0.001 |
gckb | 0.04 ± 0.07a | 2.81 ± 1.10b | 0.01 ± 0.01a | <0.001 |
pfkla | 1.06 ± 0.30a | 1.52 ± 0.47b | 0.77 ± 0.27a | <0.001 |
pfklb | 0.99 ± 0.21ab | 1.20 ± 0.34b | 0.72 ± 0.24a | 0.003 |
pfkmaa | 1.05 ± 0.60 | 1.27 ± 0.31 | 0.87 ± 0.29 | 0.148 |
pfkmab | 1.17 ± 0.59 | 1.27 ± 0.13 | 0.81 ± 0.37 | 0.060 |
pfkmba | 0.29 ± 0.25a | 2.77 ± 3.19b | 0.10 ± 0.09a | 0.009 |
pfkmbb | 1.08 ± 0.47 | 1.10 ± 0.13 | 0.73 ± 0.27 | 0.038 |
pklr | 1.07 ± 0.41ab | 1.40 ± 0.39b | 0.78 ± 0.28a | 0.006 |
Gluconeogenesis | ||||
pck1 | 0.57 ± 0.45a | 0.82 ± 0.37ab | 1.39 ± 0.74b | 0.012 |
pck2 | 0.67 ± 0.71 | 1.42 ± 0.65 | 0.79 ± 0.62 | 0.053 |
fbp1b1 | 1.06 ± 0.31 | 0.97 ± 0.20 | 1.03 ± 0.46 | 0.834 |
fbp1b2 | 0.97 ± 0.25 | 1.02 ± 0.25 | 0.98 ± 0.43 | 0.946 |
fbp1a | 0.95 ± 0.19a | 1.23 ± 0.21b | 0.83 ± 0.29a | 0.004 |
g6pca | 1.12 ± 0.41 | 0.78 ± 0.23 | 1.01 ± 0.33 | 0.105 |
g6pcb1 | 0.87 ± 0.30 | 1.07 ± 0.26 | 0.98 ± 0.47 | 0.486 |
g6pcb2 | 1.02 ± 0.47 | 0.96 ± 0.59 | 1.30 ± 0.68 | 0.449 |
Pyruvate conversion | ||||
ldhaa | 0.93 ± 0.31a | 1.86 ± 0.60b | 0.50 ± 0.26a | <0.001 |
ldhab | 0.83 ± 0.27a | 1.91 ± 0.61b | 0.54 ± 0.31a | <0.001 |
Lactate transport | ||||
slc16a3a | 1.24 ± 0.49 | 1.04 ± 0.58 | 0.88 ± 0.64 | 0.412 |
slc16a3b | 1.19 ± 0.29ab | 0.83 ± 0.20a | 1.52 ± 0.63b | 0.007 |