Table 3 Highly conserved miRNA-29b target genes involved in the regulation of insulin, glucose and energy homeostasis and branched-chain amino acid metabolism
Gene | Expressed protein | Seed sequence |
|---|---|---|
IGF1 | Insulin-like growth factor 1 | ACCACGA |
IRS1 | Insulin receptor substrate 1 | ACCACGA |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit 1 | ACCACGA |
PTEN | Phosphatase and tensin homolog | ACCACGA |
ENHO | Energy-homeostasis associated protein | ACCACGA |
FOS | V-FOS FBJ murine osteosarcoma viral oncogene homolog | ACCACGA |
VEGFA | Vascular endothelial growth factor A | ACCACGA |
DNMT3A | DNA methyltransferase 3A | ACCACGA |
SPARC | Secreted protein, acidic, cysteine-rich | ACCACGA |
DBT | Dihydrolipoamide branched-chain transacylase | ACCACGA |
PRKAB2 | AMP-activated kinase subunit B2 | ACCACGA |
SLC16A1 | Monocarboxylic acid transporter 1 | ACCACGA |
ONECUT2 | One cut homeobox 2 | ACCACGA |
MCL1 | Myeloid cell leukemia sequence 1 | ACCACGA |
PPARGC1A | Peroxisome proliferator-activated receptor- γ, co-activator 1 α | ACCACGA |
MAFB | V-MAF musculoaponeurotic fibrosarcoma oncogene family, protein B | ACCACGA |