CoQ10 enhances PGC1α and increases expression of mitochondrial antioxidant proteins in chronically ischemic swine myocardium

Table 1 List of metabolic peptides significantly upregulated following CoQ10 supplementation as measured by TMT proteomic analysis

Peptide	Accession Number	Permutation Test (p-value) Benjamini-Hochberg (p < 0.00834)	Log Fold Change (HM + CoQ10 / HM + Placebo)
ATP binding cassette subfamily B member 8	I3LMV8_PIG	0.0037	0.2
ATP synthase subunit alpha	A0A287AGU2_PIG (+ 1)	0.001	0.1
Citrate synthase	CISY_PIG	0.003	0.2
Coenzyme Q10A	F1SLZ5_PIG	0.1	0.2
Coenzyme Q10B	F1SMZ8_PIG	0.034	0.34
Coenzyme Q8A	A0A286ZK64_PIG	0.001	0.28
Coenzyme Q9	I3LHS7_PIG	0.005	0.26
Glutamate dehydrogenase 1	F1SEN2_PIG	0.003	0.19
Malate dehydrogenase	I3LP41_PIG (+ 1)	< 0.0001	0.22
Methylcrotonoyl-CoA carboxylase 2	A0A287B773_PIG	0.003	0.23
Mitochondrial import inner membrane translocase subunit TIM44	A0A287ADX5_PIG	0.00095	0.2
NAD-dependent protein deacylase sirtuin-5	A0A287AF07_PIG	0.001	0.3
NADH:ubiquinone oxidoreductase subunit V3	I3LRR4_PIG [2]	< 0.0001	0.35
NADH-cytochrome b5 reductase	F1S4N2_PIG	0.001	0.23
Oxoglutarate dehydrogenase	F1SSH8_PIG [3]	0.003	0.15
Propionyl-CoA carboxylase alpha	A0A287ALU0_PIG (+ 2)	0.006	0.14
Pyruvate dehydrogenase E1 component subunit alpha	I3LCI2_PIG	0.00019	0.21
Succinate--CoA ligase [ADP-forming] subunit beta	A0A287AR48_PIG (+ 1)	0.001	0.26
Succinate--CoA ligase [GDP-forming] subunit beta	A0A286ZWJ9_PIG	0.00026	0.2
Succinyl-CoA:3-ketoacid coenzyme A transferase 1	SCOT1_PIG	0.003	0.13
Superoxide dismutase	A0A287A4Z2_PIG (+ 1)	0.001	0.2

ISSN: 1743-7075