Fig. 8

a A representative section of the kidney showing the normal appearance of the glomerulus (red arrow) and renal tubules (black arrow) in control rats. b A representative sections of the kidney of a rat treated with streptozotcin showing most of the glomeruli degenerated with wide urinary space (red star), while others showed lobulation (olive green arrow). Vacuolar degeneration in some tubular epithelial cells (yellow arrow). Sings of degeneration in the form of pyknosis (black arrow),and focal necrosis in some tubular epithelial cells. c A representative section of the kidney of diabetic rat treated with folic acid showing degeneration in some glomeruli (star), vacuolar degeneration in some tubular epithelial cells, destruction of brush border (arrow), and hemorrhage in interstitial tissue (yellow arrow). d A representative section of the kidney of diabetic rats treated with melatonin. Some tubules appeared normal and others with vacuolar degeneration in tubular epithelial cells (red arrow), and cell debris in the lumen in some tubules (blue arrow). e A representative section of the kidney of diabetic rats treated with folic acid and melatonin showing normal glomeruli (red arrow),and most tubules appearing normal. Some tubular epithelial cells with vacuolar degeneration ((yellow arrow) and hyaline cast in the lumen of some tubules (black arrow) were seen. f A representative section of the kidney of diabetic rat treated with glibenclamide showing normal structure of most of tubules, interstitial hemorrhage (curved arrow), and normal glomerulus (straight arrow). (Hx&Ex400)