Table 1 Histological score (−: no change) and (+++: severe damage) of the histopathological changes in the renal tissues in control rats and diabetic, diabetic treated with melatonin, folic acid and melatonin with folic acid or glibenclamide
From: Folic acid and melatonin mitigate diabetic nephropathy in rats via inhibition of oxidative stress
|  | Control | DM | DM + Melatonin | DM + Folic acid | DM+ Melatonin + Folic acid | Glibenclamide |
|---|---|---|---|---|---|---|
Degenerated glomeruli | – | +++ | ++ | + | – | – |
Wide urinary space | – | +++ | + | + | – | – |
Degenerated tubular cells | – | +++ | ++ | + | – | – |
Swollen tubular cells | – | +++ | ++ | ++ | – | – |
Cells pink cytoplasm | – | +++ | ++ | + | – | – |
Oedematous glomeruli | – | +++ | + | + | – | – |
Interstitial haemorrhage | – | + | + | – | – | ++ |