Fig. 2

Expression analysis of hepatic oxidative stress marker genes in rats fed atherogenic diets and gavaged with sitagliptin. SD rats were fed Con or Met or Cho or MetCho diets ad libitum. All animals in the Met, Cho, and MetCho groups were orally gavaged with an aqueous suspension of sitagliptin (100 mg/kg/day) from day 10 through day 35, while half of the rats in the Con group were gavaged with vehicle and half the animals were gavaged with sitagliptin. At the end of the 5 weeks, livers were harvested and gene expression of hepatic oxidative stress markers, Inos (a), Lox1 (b) and Nox2 (c) was measured. Data are represented as the mean ± SEM (n = 7 per group) and means annotated with different letters differ at p < 0.05