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Fig. 3 | Nutrition & Metabolism

Fig. 3

From: High levels of dietary methionine improves sitagliptin-induced hepatotoxicity by attenuating oxidative stress in hypercholesterolemic rats

Fig. 3

Sitagliptin exacerbates expression of hepatic oxidative stress marker genes in rats fed a high Cho diet. SD rats were fed Con, Cho, or MetCho diets ad libitum. As described in methods, from day 10 to 35, 50% of rats in each dietary group were gavaged with either vehicle or an aqueous suspension of sitagliptin (100mg/kg/day) and gene expression of Inos (a), Lox1 (b) and Nox2 (c) were measured. Data are represented as the mean ± SEM (n = 7–8 per group) and means annotated with different letters differ at p < 0.05

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Nutrition & Metabolism

ISSN: 1743-7075

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