Fig. 3

Histopathological changes in IMQ mice. (a) Normal skin structure on the back indicated by only 1–2 layers of cells in the epidermis. (b) Group A: evident acanthosis, granular layer was absent focally, and moderate infiltration of lymphocytes and histocytes in the dermis. (c) Group B: typical Munro abscess was formed (blue arrow). Inflammatory cell infiltration was more severe. Similar changes were observed in the ears of the control groups (d) and group B (e). Characteristic Munro abscess was indicated with blue arrow in (f). a-f: hematoxylin and eosin; a-e original magnification × 200; F: original magnification × 400