Fig. 4

Immunochemistry and RT-qPCR of RBP4 and STRA6 expression. (a) Lesional skin had a higher level of RBP4 mRNA expression compared with non-lesional areas (p = 0.273). Immunohistochemistry results of RBP4 in the control groups (b), normal skin from group A (c), lesional skin from group A (d), non-lesional skin from group B (e), and lesional skin from group B (f). Protein levels of RBP4 accumulated in the epidermis over time. (g) Compared with normal skin, the STRA6 mRNA level was significantly higher in IMQ lesional skin (p = 0.021). STRA6 immunohistochemistry results of the control groups’ skin (h), normal skin of group A (i), lesional skin of group A (j), normal skin of group B (k), and lesional skin of group B (l). IMQ induced psoriasis-like skin lesion that contained a relatively higher level of STRA6. b-f and h-l: DAB, original magnification × 200