Fig. 9

Proposed vitamin A metabolic alterations in the psoriasis model mouse. The need for retinol in psoriasis lesional skin was increased. To meet this need, RBP4 and STRA6 were upregulated in both serum and psoriatic skin to transfer more retinol inside target cells. The transformation from retinol to RA was also accelerated, by further binding with its receptor, RA induced more synthesis of STRA6, forming a positive feedback loop