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Table 2 Multivariable linear regression analysis for the association of RBP4 in the first trimester and second trimester with fasting insulin, HOMA-IR and QUICKI in the second trimester

From: Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

 fasting insulin in 2nd trimesterHOMA-IR in 2nd trimesterQUICKI in the 2nd trimester
βP valueβP valueβP value
RBP4 in the 1st trimester
 Model 1a1.254< 0.0010.275< 0.001−2.92 × 10−3< 0.001
 Model 2b1.230< 0.0010.270< 0.001−2.84 × 10− 3< 0.001
 Model 3c1.237< 0.0010.271< 0.001−2.88 × 10−3< 0.001
RBP4 in the 2nd trimester
 Model 1a1.436< 0.0010.312< 0.001−3.32 × 10− 3< 0.001
 Model 2b1.422< 0.0010.309< 0.001−3.23 × 10− 3< 0.001
 Model 3c1.424< 0.0010.310< 0.001−3.25 × 10− 3< 0.001
  1. Abbreviations: RBP4 Retinol-binding protein 4, HOMA-IR Homeostatic model assessment for insulin resistance, QUICKI Quantitative insulin sensitivity check index
  2. a Model 1: adjusted for maternal age, education, occupation, gestational weeks of RBP4 measurements in the first trimester, pre-pregnancy BMI, GWG before OGTT, SBP, DBP
  3. b Model 2: Model 1 additional adjusted total cholesterol, triglyceride, HDL, LDL, GFR, ALT, AST
  4. c Model 3: Model 2 additional adjusted daily intake of calories and weekly physical activity time