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Table 2 The significant variations in serum metabolite indexes before- and after-marathon groups

From: Runners' metabolomic changes following marathon

Pathway Metabolite name (pubchem ID) before after p-value
Ascorbate and aldarate metabolism L-Threonate(983) 1.5382 ± 0.2986 2.1988 ± 0.3328 5.79 × 10− 8
myo-Inositol(2148) 0.4216 ± 0.1516 0.7572 ± 0.2611 5.08 × 10− 5
D-galacturonic acid(2578) 0.09 95 ± 0.0190 0.1950 ± 0.0649 7.66 × 10−6
L-Arabinono-1,4-lactone(6329) 0.1846 ± 0.0616 0.3516 ± 0.1631 0.0005
Glyoxylate and dicarboxylate metabolism Glyceric acid(378) 0.2275 ± 0.0437 0.3689 ± 0.0944 5.69 × 10−6
Mesaconic acid(812) 0.0475 ± 0.0082 0.0759 ± 0.0133 1.47 × 10− 6
L-Malic acid(927) 0.0756 ± 0.0221 0.1285 ± 0.0408 4.22 × 10− 5
cis-Aconitate(1987) 0.0242 ± 0.004 0.0399 ± 0.0078 4.56 × 10− 8
Phenylalanine metabolism trans-cinnamate(1311) 0.2978 ± 0.0600 0.4957 ± 0.1099 3.41 × 10− 7
Vanillin(1396) 0.1815 ± 0.1291 0.3046 ± 0.0986 0.0018
4-Hydroxycinnamic acid(1726) 0.2163 ± 0.0796 0.3401 ± 0.1022 9.07 × 10− 5
Carbon metabolism Glyceric acid(378) 0.2275 ± 0.0437 0.3689 ± 0.0944 5.70 × 10−6
Mesaconic acid(812) 0.0475 ± 0.0082 0.0759 ± 0.0133 1.47 × 10−8
L-Malic acid(927) 0.0756 ± 0.0221 0.1285 ± 0.0408 4.22 × 10− 5
ABC transporters myo-Inositol(2148) 0.4216 ± 0.1516 0.7572 ± 0.2611 5.08 × 10−5
D-Sorbitol(2225) 0.4259 ± 0.0923 0.2469 ± 0.0530 9.56 × 10−8
D-galacturonic acid(2578) 0.0995 ± 0.0190 0.1950 ± 0.0649 7.66 × 10− 6
D-Biotin(5747) 1.4304 ± 0.3142 0.8752 ± 0.1676 0.0007
Citrate cycle (TCA cycle) Pyruvate(182) 0.3757 ± 0.1574 0.8178 ± 0.4326 0.0005
L-Malic acid(927) 0.0756 ± 0.0221 0.1285 ± 0.0408 4.22 × 10−5
cis-Aconitate(1987) 0.0242 ± 0.004 0.0399 ± 0.0078 4.56 × 10−6
Pentose and glucuronate interconversions Ribitol(1400) 0.0573 ± 0.0158 0.0819 ± 0.0152 1.09 × 10−5
D-galacturonic acid(2578) 0.0995 ± 0.0190 0.1950 ± 0.0649 7.66 × 10−6
Galactose metabolism myo-Inositol(2148) 0.4216 ± 0.1516 0.7572 ± 0.2611 5.08 × 10−5
D-Sorbitol(2225) 0.2469 ± 0.0530 0.4259 ± 0.0923 9.56 × 10−8
Galactonic acid(2637) 0.1232 ± 0.0333 0.1895 ± 0.0447 3.05 × 10−6
Alanine aspartate and glutamate metabolism L-Asparagine(879) 0.1203 ± 0.0102 0.0974 ± 0.0114 4.27 × 10−8
N-Acetylaspartylglutamate(6623) 0.0052 ± 0.0009 0.0075 ± 0.0011 3.18 × 10−9
Amino sugar and nucleotide suger metabolism D-galacturonic acid(2578) 0.0995 ± 0.0190 0.1950 ± 0.0649 7.66 × 10−6
Glucosamine(2809) 0.1950 ± 0.0319 0.1284 ± 0.0208 2.68 × 10−9
N-Acetylmannosamine(2874) 0.0279 ± 0.0024 0.0341 ± 0.0048 3.45 × 10−5
2-Oxocarboxylic acid metabolism cis-Aconitate(1987) 0.0242 ± 0.004 0.0399 ± 0.0078 4.56 × 10−8
N-Acetyl-L-glutamate(2440) 0.0158 ± 0.0025 0.0206 ± 0.0033 3.50 × 10−6
Central carbon metabolism in cancer L-Asparagine(879) 0.1203 ± 0.0102 0.0974 ± 0.0114 4.27 × 10−8
L-Malic acid(927) 0.0756 ± 0.0221 0.1285 ± 0.0408 4.22 × 10−5
Pentose phosphate pathway Pyruvate(182) 0.3757 ± 0.1574 0.8178 ± 0.4326 0.0005
Glyceric acid(378) 0.2275 ± 0.0437 0.3689 ± 0.0944 5.70 × 10−6
Pyrimidine metabolism Beta-Alanine(2102) 0.1499 ± 0.0676 0.2418 ± 0.0799 0.0003
Cytidine5’-monophosphate(7878) 0.0597 ± 0.0470 0.1394 ± 0.0870 0.0018
Purine metabolism Adenine(949) 0.0192 ± 0.0060 0.0347 ± 0.0087 4.22 × 10−5
Hypoxanthine(984) 1.0917 ± 0.2040 1.7128 ± 0.6085 0.0005
L-Glutamine(1262) 3.7482 ± 0.5189 3.4252 ± 0.4635 0.0029
Inosine(5198) 0.4593 ± 0.3814 0.2995 ± 0.1637 9.31 × 10− 5
Caffeine metabolism Theophylline(2152) 0.5386 ± 0.5401 1.0722 ± 0.7971 0.0041
Theobromine(2187) 0.0432 ± 0.0463 0.0544 ± 0.0465 0.0025
Steroid hormone biosynthesis Hydrocortisone (10493) 0.0927 ± 0.0441 0.1241 ± 0.0279 0.0017
Phenylalanine metabolism 4-Hydroxycinnamic acid(1726) 0.2163 ± 0.0796 0.3401 ± 0.1022 9.07 × 10−5
L-Tyrosine(2870) 0.0172 ± 0.0038 0.0198 ± 0.0031 0.0001