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Fig. 4 | Nutrition & Metabolism

Fig. 4

From: Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning

Fig. 4

Indirubin treatment decreases adipose tissue mass and adipocyte cell size in HFD-induced obese mice. a Mean tissue weights of BAT, iWAT, and eWAT of mice fed NCD or HFD after 8-week treatment with either vehicle or indirubin. b Representive photographs of BAT, iWAT, and eWAT in HFD-induced obese mice after 8-week treatment with either vehicle or indirubin. c Representative hematoxylin and eosin (H&E) staining images of BAT, iWAT, and eWAT of mice fed NCD or HFD after 8-week treatment with either vehicle or indirubin. Scale bar = 50 μm. d Mean adipocyte size of adipose tissues quantified from H&E-stained section in c, six fields per mouse, using Metaxpress software. Data in a, d, e and f are presented as mean ± SD (n = 6 in each group). #p < 0.05, ###p < 0.001 compared with NCD + vehicle group; *p < 0.05, **p < 0.01, compared with HFD + vehicle group

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Nutrition & Metabolism

ISSN: 1743-7075

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