Fig. 1

Experimental protocol. After 2 weeks of acclimatization, trehalase KO mice were divided into 3 groups and WT mice were divided into 2 groups matched by body weight and then administered with 0.3% (w/v) trehalose in the drinking water or water alone. The mice were euthanized after 8 weeks. Histological examination of the intestine was carried out and measurement of adipocyte size and the rate of jejunal lipid accumulation was conducted by image analysis and serum lipid analysis, respectively