Table 3 HR (95% CI) of stratified analysis across tertiles of serum choline levels
From: Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study
Liver cancer-specific survival | Overall survival | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
T1 | T2 | T3 | P-trend | P-interaction | T1 | T2 | T3 | P-trend | P-interaction | |
Sexa, b | 0.511 | 0.781 | ||||||||
Men | 1.00 | 0.77 (0.56–1.07) | 0.66 (0.48–0.92) | 0.013 | 1.00 | 0.80 (0.58–1.10) | 0.71 (0.52–0.98) | 0.037 | ||
Women | 1.00 | 1.21 (0.41–3.52) | 1.59 (0.57–4.44) | 0.360 | 1.00 | 1.15 (0.42–3.14) | 1.33 (0.50–3.54) | 0.567 | ||
Agea, b, years | 0.838 | 0.801 | ||||||||
< 60 | 1.00 | 1.03 (0.72–1.48) | 0.69 (0.48–0.99) | 0.031 | 1.00 | 1.07 (0.75–1.52) | 0.74 (0.52–1.06) | 0.070 | ||
≥ 60 | 1.00 | 0.80 (0.42–1.51) | 0.63 (0.34–1.17) | 0.142 | 1.00 | 0.83 (0.45–1.53) | 0.65 (0.36–1.18) | 0.155 | ||
BMIa, b, kg/m2 | 0.357 | 0.436 | ||||||||
< 25.0 | 1.00 | 0.90 (0.64–1.27) | 0.74 (0.53–1.04) | 0.079 | 1.00 | 0.88 (0.62–1.23) | 0.77 (0.55–1.07) | 0.117 | ||
≥ 25.0 | 1.00 | 1.15 (0.54–2.44) | 0.47 (0.20–1.10) | 0.118 | 1.00 | 1.03 (0.50–2.12) | 0.61 (0.28–1.32) | 0.185 | ||
Smoking statusa, b | 0.820 | 0.756 | ||||||||
Smoker | 1.00 | 0.58 (0.39–0.85) | 0.57 (0.39–0.83) | 0.010 | 1.00 | 0.61 (0.42–0.89) | 0.61 (0.42–0.88) | 0.013 | ||
Non-smoker | 1.00 | 1.17 (0.69–1.98) | 0.85 (0.50–1.42) | 0.481 | 1.00 | 1.19 (0.71–2.01) | 0.91 (0.55–1.51) | 0.669 | ||
Drinking statusa, b | 0.388 | 0.399 | ||||||||
Drinker | 1.00 | 0.67 (0.41–1.07) | 0.78 (0.50–1.22) | 0.342 | 1.00 | 0.71 (0.44–1.13) | 0.75 (0.48–1.16) | 0.237 | ||
Non-Drinker | 1.00 | 1.23 (0.82–1.86) | 0.72 (0.47–1.12) | 0.077 | 1.00 | 1.16 (0.77–1.74) | 0.74 (0.49–1.13) | 0.135 | ||
AFP levela, b, ng/mL | 0.160 | 0.566 | ||||||||
≥ 400 | 1.00 | 0.85 (0.56–1.30) | 0.80 (0.52–1.22) | 0.300 | 1.00 | 0.86 (0.57–1.29) | 0.83 (0.56–1.25) | 0.385 | ||
< 400 | 1.00 | 0.87 (0.55–1.37) | 0.68 (0.43–1.06) | 0.085 | 1.00 | 0.91 (0.58–1.42) | 0.73 (0.48–1.13) | 0.155 | ||
CRP levela, b, mg/L | 0.010 | 0.005 | ||||||||
≥ 3.0 | 1.00 | 0.91 (0.64–1.29) | 0.60 (0.41–0.88) | 0.008 | 1.00 | 0.92 (0.65–1.29) | 0.63 (0.44–0.91) | 0.013 | ||
< 3.0 | 1.00 | 1.34 (0.70–2.56) | 1.37 (0.74–2.51) | 0.353 | 1.00 | 1.34 (0.71–2.54) | 1.47 (0.81–2.67) | 0.224 | ||
Serum folate levela, b | 0.782 | 0.946 | ||||||||
High | 1.00 | 1.07 (0.67–1.70) | 0.79 (0.50–1.26) | 0.279 | 1.00 | 1.17 (0.74–1.84) | 0.91 (0.58–1.43) | 0.583 | ||
Low | 1.00 | 0.96 (0.62–1.47) | 0.77 (0.50–1.17) | 0.207 | 1.00 | 0.94 (0.62–1.42) | 0.76 (0.50–1.14) | 0.170 | ||
Liver damage levela, b | 0.520 | 0.602 | ||||||||
1 | 1.00 | 1.39 (0.34–5.74) | 1.54 (0.40–6.00) | 0.547 | 1.00 | 1.85 (0.52–6.62) | 1.16 (0.34–3.97) | 0.935 | ||
2 | 1.00 | 1.06 (0.63–1.78) | 0.58 (0.33–1.01) | 0.045 | 1.00 | 1.06 (0.63–1.78) | 0.65 (0.38–1.13) | 0.114 | ||
≥ 3 | 1.00 | 0.82 (0.55–1.22) | 0.72 (0.48–1.08) | 0.115 | 1.00 | 0.86 (0.58–1.26) | 0.78 (0.53–1.14) | 0.206 | ||
Presence of fatty livera, b | 0.385 | 0.842 | ||||||||
Yes | 1.00 | 1.08 (0.38–3.07) | 0.94 (0.32–2.78) | 0.902 | 1.00 | 1.05 (0.40–2.76) | 1.17 (0.45–3.03) | 0.741 | ||
No | 1.00 | 0.94 (0.68–1.30) | 0.69 (0.50–0.97) | 0.026 | 1.00 | 0.96 (0.70–1.32) | 0.72 (0.52–0.99) | 0.035 | ||
Presence of cirrhosisa, b | 0.518 | 0.170 | ||||||||
Yes | 1.00 | 0.93 (0.60–1.43) | 0.83 (0.54–1.27) | 0.380 | 1.00 | 0.93 (0.61–1.42) | 0.90 (0.60–1.35) | 0.602 | ||
No | 1.00 | 0.98 (0.63–1.52) | 0.63 (0.39–1.00) | 0.048 | 1.00 | 1.01 (0.66–1.56) | 0.62 (0.39–0.98) | 0.039 | ||
BCLC stagea, b | 0.774 | 0.502 | ||||||||
0/A | 1.00 | 0.80 (0.34–1.90) | 0.72 (0.32–1.62) | 0.440 | 1.00 | 0.91 (0.40–2.11) | 0.78 (0.35–1.73) | 0.515 | ||
B/C | 1.00 | 0.89 (0.64–1.23) | 0.64 (0.46–0.90) | 0.008 | 1.00 | 0.88 (0.63–1.21) | 0.67 (0.48–0.93) | 0.014 | ||
Treatmenta, b | 0.333 | 0.480 | ||||||||
Liver resection | 1.00 | 1.29 (0.69–2.41) | 0.81 (0.42–1.56) | 0.536 | 1.00 | 1.16 (0.63–2.14) | 0.87 (0.46–1.62) | 0.664 | ||
Intervention | 1.00 | 0.75 (0.51–1.10) | 0.60 (0.41–0.86) | 0.006 | 1.00 | 0.80 (0.55–1.17) | 0.64 (0.45–0.92) | 0.015 | ||
Others | 1.00 | 1.26 (0.52–3.07) | 0.95 (0.37–2.42) | 0.908 | 1.00 | 1.21 (0.49–2.94) | 1.00 (0.40–2.50) | 0.985 | ||