Table 4 HR (95% CI) of stratified analysis across tertiles of serum betaine levels
From: Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study
Liver cancer-specific survival | Overall survival | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
T1 | T2 | T3 | P-trend | P-interaction | T1 | T2 | T3 | P-trend | P-interaction | |
Sexa, b | 0.229 | 0.328 | ||||||||
Men | 1.00 | 0.95 (0.70–1.29) | 0.73 (0.53–0.99) | 0.046 | 1.00 | 0.94 (0.70–1.27) | 0.76 (0.56–1.03) | 0.078 | ||
Women | 1.00 | 0.91 (0.30–2.74) | 1.30 (0.45–3.74) | 0.590 | 1.00 | 0.83 (0.31–2.24) | 1.36 (0.53–3.47) | 0.504 | ||
Agea, b, years | 0.627 | 0.721 | ||||||||
< 60 | 1.00 | 1.01 (0.72–1.43) | 0.88 (0.62–1.25) | 0.460 | 1.00 | 1.01 (0.73–1.41) | 0.89 (0.64–1.25) | 0.505 | ||
≥ 60 | 1.00 | 1.17 (0.65–2.13) | 0.86 (0.47–1.58) | 0.586 | 1.00 | 1.19 (0.67–2.14) | 0.90 (0.50–1.62) | 0.678 | ||
BMIa, b, kg/m2 | 0.702 | 0.574 | ||||||||
< 25.0 | 1.00 | 1.01 (0.73–1.39) | 0.85 (0.61–1.18) | 0.331 | 1.00 | 0.96 (0.70–1.32) | 0.84 (0.62–1.15) | 0.276 | ||
≥ 25.0 | 1.00 | 2.06 (0.89–4.75) | 1.78 (0.76–4.15) | 0.218 | 1.00 | 1.90 (0.87–4.15) | 1.37 (0.61–3.07) | 0.526 | ||
Smoking statusa, b | 0.097 | 0.050 | ||||||||
Smoker | 1.00 | 1.16 (0.81–1.68) | 0.76 (0.52–1.11) | 0.153 | 1.00 | 1.13 (0.79–1.61) | 0.79 (0.55–1.13) | 0.187 | ||
Non-smoker | 1.00 | 0.90 (0.54–1.50) | 1.04 (0.64–1.69) | 0.884 | 1.00 | 0.89 (0.54–1.46) | 1.05 (0.65–1.69) | 0.837 | ||
Drinking statusa, b | 0.176 | 0.227 | ||||||||
Drinker | 1.00 | 0.96 (0.61–1.51) | 0.98 (0.62–1.54) | 0.932 | 1.00 | 0.97 (0.62–1.52) | 0.98 (0.63–1.52) | 0.935 | ||
Non-Drinker | 1.00 | 0.99 (0.67–1.46) | 0.78 (0.52–1.17) | 0.226 | 1.00 | 0.97 (0.66–1.41) | 0.77 (0.52–1.13) | 0.187 | ||
AFP levela, b, ng/mL | 0.527 | 0.194 | ||||||||
≥ 400 | 1.00 | 1.03 (0.69–1.54) | 0.96 (0.63–1.45) | 0.853 | 1.00 | 0.94 (0.64–1.38) | 0.93 (0.63–1.38) | 0.703 | ||
< 400 | 1.00 | 1.25 (0.81–1.95) | 0.87 (0.55–1.37) | 0.609 | 1.00 | 1.28 (0.83–1.99) | 0.98 (0.63–1.52) | 0.832 | ||
CRP levela, b, mg/L | 0.329 | 0.379 | ||||||||
≥ 3.0 | 1.00 | 0.87 (0.61–1.23) | 0.87 (0.61–1.24) | 0.446 | 1.00 | 0.83 (0.59–1.17) | 0.89 (0.63–1.24) | 0.504 | ||
< 3.0 | 1.00 | 1.34 (0.78–2.31) | 0.70 (0.38–1.31) | 0.287 | 1.00 | 1.39 (0.82–2.35) | 0.81 (0.45–1.46) | 0.525 | ||
Serum folate levela, b | 0.250 | 0.387 | ||||||||
High | 1.00 | 1.27 (0.82–1.96) | 0.86 (0.54–1.37) | 0.545 | 1.00 | 1.17 (0.77–1.78) | 0.91 (0.59–1.41) | 0.674 | ||
Low | 1.00 | 1.03 (0.68–1.54) | 0.92 (0.62–1.38) | 0.695 | 1.00 | 1.01 (0.68–1.51) | 0.93 (0.63–1.37) | 0.700 | ||
Liver damage levela, b | 0.145 | 0.313 | ||||||||
1 | 1.00 | 1.66 (0.50–5.49) | 0.63 (0.14–2.86) | 0.536 | 1.00 | 1.19 (0.40–3.55) | 0.60 (0.17–2.14) | 0.396 | ||
2 | 1.00 | 1.46 (0.87–2.45) | 1.11 (0.66–1.89) | 0.716 | 1.00 | 1.47 (0.88–2.47) | 1.24 (0.74–2.09) | 0.430 | ||
≥ 3 | 1.00 | 0.83 (0.56–1.24) | 0.84 (0.57–1.24) | 0.398 | 1.00 | 0.84 (0.57–1.23) | 0.84 (0.58–1.22) | 0.361 | ||
Presence of fatty livera, b | 0.664 | 0.333 | ||||||||
Yes | 1.00 | 1.39 (0.46–4.19) | 1.49 (0.53–4.20) | 0.461 | 1.00 | 1.56 (0.57–4.24) | 1.76 (0.69–4.51) | 0.245 | ||
No | 1.00 | 1.04 (0.77–1.42) | 0.81 (0.59–1.11) | 0.194 | 1.00 | 1.03 (0.76–1.39) | 0.83 (0.61–1.12) | 0.225 | ||
Presence of cirrhosisa, b | 0.136 | 0.069 | ||||||||
Yes | 1.00 | 1.28 (0.85–1.95) | 0.89 (0.59–1.35) | 0.552 | 1.00 | 1.27 (0.85–1.91) | 0.95 (0.64–1.40) | 0.732 | ||
No | 1.00 | 1.04 (0.67–1.60) | 0.76 (0.48–1.19) | 0.164 | 1.00 | 0.87 (0.57–1.35) | 0.71 (0.46–1.10) | 0.118 | ||
BCLC stagea, b | 0.653 | 0.632 | ||||||||
0/A | 1.00 | 1.51 (0.69–3.27) | 1.06 (0.46–2.46) | 0.900 | 1.00 | 1.63 (0.76–3.50) | 1.11 (0.52–2.40) | 0.822 | ||
B/C | 1.00 | 0.94 (0.66–1.33) | 0.84 (0.59–1.19) | 0.325 | 1.00 | 0.91 (0.65–1.28) | 0.87 (0.62–1.21) | 0.405 | ||
Treatmenta, b | 0.292 | 0.305 | ||||||||
Liver resection | 1.00 | 1.24 (0.67–2.30) | 1.02 (0.53–1.98) | 0.945 | 1.00 | 1.14 (0.64–2.03) | 0.88 (0.48–1.64) | 0.720 | ||
Intervention | 1.00 | 0.82 (0.57–1.17) | 0.67 (0.46–0.97) | 0.032 | 1.00 | 0.82 (0.58–1.17) | 0.72 (0.50–1.02) | 0.065 | ||
Others | 1.00 | 1.41 (0.57–3.48) | 0.84 (0.32–2.20) | 0.668 | 1.00 | 1.47 (0.60–3.64) | 1.03 (0.41–2.59) | 0.974 | ||