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Table 1 Flutamide reversed the enhancement of IGF-1R and mTOR at mRNA levels induced by trainings

From: Crucial role of androgen receptor in resistance and endurance trainings-induced muscle hypertrophy through IGF-1/IGF-1R- PI3K/Akt- mTOR pathway

 nGastrocnemiusSoleus
IGF-1RmTORIGF-1RmTOR
C71.00 ± 0.231.00 ± 0.181.00 ± 0.201.00 ± 0.21
F60.88 ± 0.110.91 ± 0.110.81 ± 0.140.85 ± 0.14
R81.32 ± 0.21*1.43 ± 0.10**//
R + F80.96 ± 0.06##0.97 ± 0.16##//
E8//1.30 ± 0.20*1.32 ± 0.28*
E + F7//0.98 ± 0.18#0.94 ± 0.27##
  1. Note: The increased mRNA levels of IGF-1R and mTOR were found in the gastrocnemius of resistance training rats and in the soleus of endurance training rats. Flutamide reversed the trainings-induced changes in IGF-1R and mTOR at mRNA level. C Control, F Flutamide embedded, R Resistance training, R + F Resistance training plus flutamide embedded, E Endurance training, E + F Endurance training plus flutamide embedded. *P<0.05, **P<0.01 vs C; #P<0.05, ##P<0.01 vs the relative training groups