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Table 1 Flutamide reversed the enhancement of IGF-1R and mTOR at mRNA levels induced by trainings

From: Crucial role of androgen receptor in resistance and endurance trainings-induced muscle hypertrophy through IGF-1/IGF-1R- PI3K/Akt- mTOR pathway

 

n

Gastrocnemius

Soleus

IGF-1R

mTOR

IGF-1R

mTOR

C

7

1.00 ± 0.23

1.00 ± 0.18

1.00 ± 0.20

1.00 ± 0.21

F

6

0.88 ± 0.11

0.91 ± 0.11

0.81 ± 0.14

0.85 ± 0.14

R

8

1.32 ± 0.21*

1.43 ± 0.10**

/

/

R + F

8

0.96 ± 0.06##

0.97 ± 0.16##

/

/

E

8

/

/

1.30 ± 0.20*

1.32 ± 0.28*

E + F

7

/

/

0.98 ± 0.18#

0.94 ± 0.27##

  1. Note: The increased mRNA levels of IGF-1R and mTOR were found in the gastrocnemius of resistance training rats and in the soleus of endurance training rats. Flutamide reversed the trainings-induced changes in IGF-1R and mTOR at mRNA level. C Control, F Flutamide embedded, R Resistance training, R + F Resistance training plus flutamide embedded, E Endurance training, E + F Endurance training plus flutamide embedded. *P<0.05, **P<0.01 vs C; #P<0.05, ##P<0.01 vs the relative training groups
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Nutrition & Metabolism

ISSN: 1743-7075

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