Table. 2 Gene Ontology analysis of mitochondria associated differentially expressed proteins

Cellular Component

mitochondrion

NDUFB11, GRPEL1, DNM1L, NDUFB7, PSAP, NDUFA7, ACACB, VDAC2, NDUFA1, GLYCTK, NMT1, YWHAH, GOT1, NDUFV2, NDUFS8, SLC25A3, BDH2, DDAH1, NDUFS2, NDUFS1, PC

mitochondrial respiratory chain complex I

NDUFB11, NDUFB7, NDUFV1, NDUFA7, NDUFV2, NDUFS8, NDUFA1, NDUFS2, NDUFA12, NDUFS1

mitochondrial inner membrane

NDUFB11, LGALS3, NDUFB7, NDUFV1, NDUFA7, NDUFV2, SLC25A3, VDAC2, NDUFA1, NDUFA12

mitochondrial matrix

GRPEL1, NDUFS8, PDHX, AGXT, NDUFS2, NDUFS1, PC

mitochondrial outer membrane

DNM1L, ACACB, VDAC2

mitochondrial intermembrane space

NDUFB7, NDUFS1

Molecular function

NADH dehydrogenase (ubiquinone) activity

NDUFB7, NDUFV1, NDUFA7, NDUFV2, NDUFS8, NDUFA1, NDUFS2, NDUFA12, NDUFS1

electron carrier activity

NDUFV2, AKR1B1, PHGDH, HAAO, SH3BGRL3, NDUFS2, NDUFA12, NDUFS1

NAD binding

AHCY, SORD, NDUFV1, PHGDH, BDH2, NDUFS2

NADH dehydrogenase activity

NDUFV1, NDUFS8, NDUFS2

oxidoreductase activity, acting on NAD(P)H

NDUFS8, NDUFS2, NDUFS1

oxidoreductase activity

PTGR2, SORD, NDUFV2, AKR1B1, ADH1C, BDH2

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

SRD5A3, BDH2

Biological process

mitochondrial electron transport, NADH to ubiquinone

NDUFB11, NDUFB7, NDUFV1, NDUFA7, NDUFV2, NDUFS8, NDUFA1, NDUFS2, NDUFA12, NDUFS1

mitochondrial respiratory chain complex I assembly

NDUFB11, NDUFB7, NDUFV1, NDUFA7, NDUFV2, NDUFS8, NDUFA1, NDUFS2, NDUFA12, NDUFS1

response to oxidative stress

EGFR, ALAD, ATOX1, NDUFS8, NDUFS2, NDUFA12, NAPRT

oxidation-reduction process

PTGR2, SORD, CYP2B6, PCBD1, HGD, CRYL1, CBR1, PRDX6, AKR1B1, FMO3, SRD5A3, HAAO, PHGDH, SH3BGRL3

steroid metabolic process

CYP2B6, SULT1B1, SULT1A1, SULT1E1

ATP synthesis coupled electron transport

NDUFA7, NDUFS1