Fig. 10

Evaluation of FGF15, FGFR4, KLB, CYP7A1, NTCP, and BSEP mRNA levels in liver tissues among the different experimental groups. a Bar chart representing the relative CYP7A1 mRNA expression level, b relative NTCP mRNA expression level, c relative BSEP mRNA expression level, d relative FGF15 mRNA expression level, e relative FGF4R expression level, and f relative KLB mRNA expression level. **P < 0.01, vs control group; ^##P < 0.01, ^#P < 0.05, vs HFD group. Data are presented as mean ± standard deviation and are the results of 2 independent experiments, n = 6. FGF15, fibroblast growth factor 15; FGFR4, fibroblast growth factor receptor 4; KLB, Klotho beta; CYP7A1, cholesterol 7-alpha hydroxy-lase; NTCP, Na + −taurocholate co-transporting polypeptide; BSEP, bile salt export protein; C, control; HFD, high-fat diet; Gyp, gypenosides; OCA, obeticholic acid