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Fig. 7 | Nutrition & Metabolism

Fig. 7

From: Effects of Royal Jelly and Tocotrienol Rich Fraction in obesity treatment of calorie-restricted obese rats: a focus on white fat browning properties and thermogenic capacity

Fig. 7

Suggested pathways for browning of white adipose tissue and brown fat activation by RJ. RJ with agonistic activity, activate temperature-sensitive TRP channels in the GI, triggering thermogenesis through the activation of the TRP-SNS-UCP1 axis. Β3-AR (β3-adrenoceptor), BMP8B (bone morphogenetic protein8B), cAMP (cyclic adenosine monophosphate), CREB1 (cAMP response element-binding protein1), NE (norepinephrine), PRDM16 (PR domain containing16), PPARγ (peroxisome proliferator-activated receptor-gamma), PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), PPARα (peroxisome proliferator-activated receptor alpha), P38 MAPK (P38 mitogen-activated protein kinase), PKA (cAMP-dependent protein kinase A), TRP (transient receptor potential) and UCP1 (uncoupling protein 1)

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Nutrition & Metabolism

ISSN: 1743-7075

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