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Fig. 3 | Nutrition & Metabolism

Fig. 3

From: High fat-induced inflammation in vascular endothelium can be improved by Abelmoschus esculentus and metformin via increasing the expressions of miR-146a and miR-155

Fig. 3

AE and metformin prevent high fat-induced fat accumulation, dyslipidemia and endothelial inflammation. a, body weight of rats after treatment with AE or metformin for 8 weeks following high fat diet for 10 weeks. b, the percent of subcutaneous fat in rats. c, the percent of visceral fat in rats. d, the fasting glucose level in rats. e-h, the TC, TG, LDL-C and HDL-C levels in serum of rats. i, relative mRNA levels of NF-κB p65, MCP-1, ICAM-1 and IL-6 in rat aortas. j, relative protein levels of p-NF-κB p65 in rat aortas. k, relative mRNA levels of NF-κB p65, MCP-1, ICAM-1 and IL-6 in HAECs. l, relative protein levels of p-NF-κB p65 in HAECs. Data are presented as mean ± SEM. *P < 0.05 versus NC or BSA group. **P < 0.01 versus NC or BSA group. #P<0.05 versus HF or PA group. ##P<0.01 versus HF or PA group. n = 6–15 rats per group for animal study. n = 5 per group for HAECs study

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