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Fig. 5 | Nutrition & Metabolism

Fig. 5

From: High fat-induced inflammation in vascular endothelium can be improved by Abelmoschus esculentus and metformin via increasing the expressions of miR-146a and miR-155

Fig. 5

AE and metformin inhibit high fat induced endothelial inflammation via regulating miR-146a and its target genes in HAECs. a, relative mRNA levels of NF-κB p65, IL-6, MCP-1 and ICAM-1 in HAECs transfected with miR-146a mimics. b, relative protein levels of p-NF-κB p65, IRAK1 and TRAF6 in HAECs transfected with miR-146a mimics. c, relative mRNA levels of NF-κB p65, IL-6, MCP-1 and ICAM-1 in HAECs transfected with miR-146a inhibitors. d, relative protein levels of p-NF-κB p65, IRAK1 and TRAF6 in HAECs transfected with miR-146a inhibitors. Data are presented as mean ± SEM. *P < 0.05 versus BSA group. **P < 0.01 versus BSA group. #P<0.05 versus control mimics or inhibitors in PA group. ##P<0.01 versus control mimics or inhibitors in PA group. &P<0.05 versus control mimics or inhibitors in PA-AE group. ΨP<0.05 versus control mimics or inhibitors in PA-Met group. n = 5 per group for HAECs study

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