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Table 2 Differentially downregulated genes in the model group and the control group with Log2FC ≤ − 2 and P < 0.05

From: High-trans fatty acid and high-sugar diets can cause mice with non-alcoholic steatohepatitis with liver fibrosis and potential pathogenesis

Gene name

Gene description

Con

(Mean)

HFHC

(Mean)

FC (HFHC/Con)

Log2FC

(HFHC/Con)

Padjust

Regulate

Adra2a

Adrenergic receptor, alpha 2a

0.47

0.02

0.04

−4.70

0.0240

Down

Serpina1e

Serine (or cysteine) peptidase inhibitor, clade A, member 1E

2355.30

94.32

0.04

−4.51

0.0052

Down

Lepr

Leptin receptor

7.01

0.54

0.06

−4.04

0.0043

Down

Cspg5

Chondroitin sulfate Proteoglycan 5

1.11

0.07

0.06

−3.96

0.0046

Down

Enho

Energy homeostasis associated

13.42

1.12

0.09

−3.52

0.0025

Down

Slc30a3

Solute carrier family 30 (zinc transporter), member 3

0.94

0.08

0.09

−3.49

0.0051

Down

Unc79

Unc-79 homolog (C. elegans)

1.15

0.14

0.13

−3.00

0.0181

Down

Gtpbp4-Ps1

GTP binding Protein 4, Pseudogene 1

54.76

5.16

0.13

−2.97

0.0083

Down

Pitx3

Paired-like homeodomain transcription factor 3

6.66

0.52

0.14

−2.87

0.0033

Down

Slc13a5

Solute carrier family 13 (sodium-dependent citrate transporter), member 5

1.25

0.20

0.14

−2.86

0.0149

Down

Fam198a

Family with sequence similarity 198, member A

5.43

0.78

0.14

−2.80

0.0052

Down

Pdk4

Pyruvate dehydrogenase kinase, isoenzyme 4

33.33

5.43

0.15

−2.74

0.0041

Down

Asns

Asparagine synthetase

1.17

0.40

0.16

−2.68

0.0161

Down

PPP1r3g

Protein phosphatase 1, regulatory (inhibitor) subunit 3G

2.54

0.41

0.16

−2.66

0.0181

Down

Fst

Follistatin

1.47

0.24

0.17

−2.60

0.0056

Down