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Table 3 KEGG signaling pathways identified in genes that are differentially expressed between the model group and the control group

From: High-trans fatty acid and high-sugar diets can cause mice with non-alcoholic steatohepatitis with liver fibrosis and potential pathogenesis

Pathway id

Description

Ratio_in_study

Ratio_in_pop

Percent

P value

Map00830

Retinol metabolism

23/665

143/22793

16.08%

1.4977E-08

Map00140

Steroid hormone biosynthesis

22/665

144/22793

15.28%

2.6183E-08

Map05204

Chemical carcinogenesis

23/665

176/22793

13.07%

1.3555E-07

Map00590

Arachidonic acid metabolism

19/665

127/22793

14.96%

2.8598E-07

Map04062

Chemokine signaling pathway

24/665

241/22793

9.96%

8.3868E-06

Map00980

Metabolism of xenobiotics by cytochrome P450

15/665

137/22793

10.95%

0.00035448

Map04750

Inflammatory mediator regulation of TRP channels

16/665

161/22793

9.94%

0.00056316

Map00100

Steroid biosynthesis

6/665

23/22793

26.09%

0.00098829

Map00591

Linoleic acid metabolism

10/665

72/22793

13.89%

0.00099817

Map00062

Fatty acid elongation

7/665

38/22793

18.42%

0.00210167

Map00982

Drug metabolism-cytochrome P450

12/665

119/22793

10.08%

0.00324254

Map04152

AMPK signaling pathway

14/665

160/22793

8.75%

0.00416512

Map03320

PPAR signaling pathway

12/665

127/22793

9.45%

0.00529036

Map00071

Fatty acid degradation

8/665

63/22793

12.70%

0.00646651

Map04923

Regulation of lipolysis in adipocytes

8/665

66/22793

12.12%

0.00846127

Map04145

Phagosome

27/665

474/22793

5.70%

0.00990327

Map01040

Biosynthesis of unsaturated fatty acids

6/665

39/22793

15.38%

0.01027708

Map00520

Amino sugar and nucleotide sugar metabolism

8/665

70/22793

11.43%

0.01099148

Map04512

ECM-receptor interaction

9/665

88/22793

10.23%

0.01163767

Map04650

Natural killer cell mediated cytotoxicity

19/665

302/22793

6.29%

0.01575303

Map04974

Protein digestion and absorption

9/665

97/22793

9.28%

0.01992439

Map04060

Cytokine-cytokine receptor interaction

19/665

311/22793

6.11%

0.02042395

Map04918

Thyroid hormone synthesis

8/665

82/22793

9.76%

0.02369879

Map04931

Insulin resistance

10/665

121/22793

8.26%

0.02475499

Map04930

Type II diabetes mellitus

7/665

69/22793

10.14%

0.03251649

Map04920

Adipocytokine signaling pathway

7/665

72/22793

9.72%

0.0399927

Map04620

Toll-like receptor signaling pathway

9/665

111/22793

8.11%

0.04083019

Map04080

Neuroactive ligand-receptor interaction

19/665

341/22793

5.57%

0.04192223

Map04666

Fc gamma R-mediated phagocytosis

15/665

244/22793

6.15%

0.0422101

Map00900

Terpenoid backbone biosynthesis

5/665

40/22793

12.50%

0.04231822

Map04012

Erbb signaling pathway

9/665

115/22793

7.83%

0.04606007