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Fig. 2 | Nutrition & Metabolism

Fig. 2

From: TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARα promoter

Fig. 2

After DNA extraction, mice were subjected to PCR and gel electrophoresis (a). Compared with WT mice, lipid accumulation in the liver of TET1 knockout mouse was compared in gross view of the liver (e), liver weight (i), body weight (g), liver index (j), H&E (d), Oil red O staining (f), Comparison of TG content in the liver (h). The levels of ALT (o), and AST (n) in the serum, and fasting blood sugar (q), fasting insulin (p), and HOMA-IR (r) values of TET1-KO mice and their littermate controls at 0–12 weeks after NC or HFD feeding. The blood glucose levels of WT and TET1-KO mice according to glucose tolerance test (GTT) (s) and insulin tolerance test (ITT) (t) at 11 weeks after HFD treatment (n = 6 mice in each group for each test)

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