The trajectory of high sensitivity C-reactive protein is associated with incident diabetes in Chinese adults

Nutrition & Metabolism

Table 3 The adjusted hazard ratios and 95% confidence interval for incident diabetes across different hs-CRP groups among 6349 Chinese adults

Variables	Model	Low-risk (< 1 mg/L)	Intermediate-risk (1–2.9 mg/L)	High-risk (≥3 mg/L)	Each SD	P trend
Baseline hs-CRP concentration^a	n	4243	1663	443	–	–
	Case #	157	105	40	–	–
	Model	1 (ref)	1.22 (0.94, 1.58)	1.67 (1.17, 2.39)	1.11 (1.01, 1.22)	0.005
Concentration of hs-CRP in 2015^b	n	4174	1787	388	–	–
	Case #	111	95	29	–	–
	Model	1 (ref)	1.44 (1.08, 1.9)	1.94 (1.28, 2.94)	1.19 (1.08, 1.30)	0.001
Cumulative average of hs-CRP concentration^b	n	5197	995	157	–	–
	Case #	171	52	12	–	–
	Model	1 (ref)	1.4 (1.001, 1.94)	1.87 (1.03, 3.39)	1.24 (1.04, 1.47)	0.008

Note:
1. Abbreviation: hs-CRP High-sensitivity C-reactive protein
2. ^a based on five years of follow up (2014–2018)
3. ^b based on three years of follow-up (2016–2018)
4. Adjusting for age (y) and sex, baseline BMI (kg/m²), systolic blood pressure (mmHg), diastolic blood pressure (mmHg), total cholesterol (mmol/L), triglyceride (mmol/L), low-density-lipoprotein cholesterol (mmol/L), high-density-lipoprotein cholesterol (mmol/L), eGFR (ml/min/1.73m²), fasting blood glucose (mmol/L), and glycated hemoglobin A1c (%)

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