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Table 2 GO analysis of predicted target genes of five validated C19MC miRNAs

From: Maternal obesity alters C19MC microRNAs expression profile in fetal umbilical cord blood

Subcategory GO name numbers P-value Targeted mRNA
positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 15 0.0005 CCR7, FGR, SRC, TNFAIP8L3, ATG14, ERBB4, FGFR3, FLT1, IRS1, PDGFB, PTK2B, PTK2, TGFB1, VAV2, VAV3
post-embryonic development GO:0009791 22 0.017 ALX4, MORC3, PLAGL2, PRDM1, SMAD2, SOX6, TAL2, TIPARP, ACVR2B, ALDH5A1, AGO2, CHST11, EMX1, GABRG2, HEG1, ITPR1, IMPAD1, KMT2A, PYGO1, SZT2, SELENOP, SOD2
memory GO:0007613 19 0.023 HTR2A, CHRFAM7A, NTAN1, SHANK2, CNR1, DRD1, EIF4EBP2, FEN1, HRH1, HRH2, ITGA3, KALRN, PAK5, PLA2G6, PLCB1, KCNK10, KCNK4, PPP3CB, SLC6A4,
response to hydrogen peroxide GO:0042542 16 0.032 BAK1, SRC, CASP3, DUSP1, GLRX2, GPX1, HP, HMOX1, MB, NR4A3, PPP1R15B, PTK2B, STK25, STAT1, SOD2, SDC
T cell differentiation GO:0030217 11 0.033 CD3D, SOX4, SP3, CHD7, IL7R, NHEJ1, PREX1, PIK3CD, PPP3CB, PTPN2, PTPN22
glucose homeostasis GO:0042593 27 0.034 ALMS1, CSMD1, HECTD4, HNF1A, SOX4, VGF, ADIPOR2, CNR1, CAV3, CRY1, CRY2, DHPS, FBN1, HNF4A, HIF1A, INPP5K, IRS1, INSR, NEUROD1, PRCP, PRKAA1, PRKAA2, PTPN2, RBP4, SLC2A4, SLC8B1, TCF7L2
MAPK cascade GO:0000165 60 0.038 BRAP, CCL5, FYN, JAK1, NDST1, RASGRP3, RASGRP4, RASA1, RASA2, RAF1, RASGEF1A, SHC3, ACTN2, CAMK2B, CAMK2D, CAMKK2, CALM3, CSF2RA, CSF2RB, DOK4, DOK5, DUSP5, DUSP7, EGFR, EREG, ERBB3, ERBB4, FGF19, FGF7, FGFR3, GRB2, ITPKB, IRS1, IL17RD, IL2RB, IL31RA, KLB, LRRK2, MAPK4, MAPK8IP2, MAPKAPK3, MEF2D, NRG1, NF1, PDGFB, PSMD1, PSMD5, PSME3, PSME4, PSMA2, PSMB4, PTK2B, PTK2, RET, SPTA1, SPTB, SPTBN1, SPRED1, TGFB1, MYC
nervous system development GO:0007399 67 0.038 MTR, DGCR14, GPSM1, RFNG, RBM45, ARHGEF7, SMARCC1, WNT8B, ZIC5, ATXN10, ATXN3, CHRM2, CHRM3, CHRDL1, CPLX2, CRIM1, DPYSL5, DOK4, DOK5, DYRK1A, EDNRB, ERBB4, FEZ1, FEZ2, FGF19, FUT10, FKTN, GBX2, GMFB, GRIK1, GPM6B, GAS7, HDAC4, IGSF9B, INSC, KALRN, LSAMP, MPPED2, MARK4, MAP1B, MBNL1, MEF2D, NRG1, NLGN1, NAV2, NR2E1, PRPS1, PCSK2, PPP2R5D, PCDHA10, PCDHA11, PCDHA2, PCDHA4, PCDHA5, PCDHA8, SEMA6A, SRRM4, SHOX2, SIGMAR1, SCN8A, TSHR, TMEM41B, TPP1, TMOD2, ZEB2,
  1. Gene names and their numbers of predicted target mRNAs are listed in each GO subcategory. P value of < 0.05 was considered significant