Table 2 GO analysis of predicted target genes of five validated C19MC miRNAs

positive regulation of phosphatidylinositol 3-kinase activity

GO:0043552

CCR7, FGR, SRC, TNFAIP8L3, ATG14, ERBB4, FGFR3, FLT1, IRS1, PDGFB, PTK2B, PTK2, TGFB1, VAV2, VAV3

post-embryonic development

GO:0009791

ALX4, MORC3, PLAGL2, PRDM1, SMAD2, SOX6, TAL2, TIPARP, ACVR2B, ALDH5A1, AGO2, CHST11, EMX1, GABRG2, HEG1, ITPR1, IMPAD1, KMT2A, PYGO1, SZT2, SELENOP, SOD2

memory

GO:0007613

HTR2A, CHRFAM7A, NTAN1, SHANK2, CNR1, DRD1, EIF4EBP2, FEN1, HRH1, HRH2, ITGA3, KALRN, PAK5, PLA2G6, PLCB1, KCNK10, KCNK4, PPP3CB, SLC6A4,

response to hydrogen peroxide

GO:0042542

BAK1, SRC, CASP3, DUSP1, GLRX2, GPX1, HP, HMOX1, MB, NR4A3, PPP1R15B, PTK2B, STK25, STAT1, SOD2, SDC

T cell differentiation

GO:0030217

CD3D, SOX4, SP3, CHD7, IL7R, NHEJ1, PREX1, PIK3CD, PPP3CB, PTPN2, PTPN22

glucose homeostasis

GO:0042593

ALMS1, CSMD1, HECTD4, HNF1A, SOX4, VGF, ADIPOR2, CNR1, CAV3, CRY1, CRY2, DHPS, FBN1, HNF4A, HIF1A, INPP5K, IRS1, INSR, NEUROD1, PRCP, PRKAA1, PRKAA2, PTPN2, RBP4, SLC2A4, SLC8B1, TCF7L2

MAPK cascade

GO:0000165

BRAP, CCL5, FYN, JAK1, NDST1, RASGRP3, RASGRP4, RASA1, RASA2, RAF1, RASGEF1A, SHC3, ACTN2, CAMK2B, CAMK2D, CAMKK2, CALM3, CSF2RA, CSF2RB, DOK4, DOK5, DUSP5, DUSP7, EGFR, EREG, ERBB3, ERBB4, FGF19, FGF7, FGFR3, GRB2, ITPKB, IRS1, IL17RD, IL2RB, IL31RA, KLB, LRRK2, MAPK4, MAPK8IP2, MAPKAPK3, MEF2D, NRG1, NF1, PDGFB, PSMD1, PSMD5, PSME3, PSME4, PSMA2, PSMB4, PTK2B, PTK2, RET, SPTA1, SPTB, SPTBN1, SPRED1, TGFB1, MYC

nervous system development

GO:0007399

MTR, DGCR14, GPSM1, RFNG, RBM45, ARHGEF7, SMARCC1, WNT8B, ZIC5, ATXN10, ATXN3, CHRM2, CHRM3, CHRDL1, CPLX2, CRIM1, DPYSL5, DOK4, DOK5, DYRK1A, EDNRB, ERBB4, FEZ1, FEZ2, FGF19, FUT10, FKTN, GBX2, GMFB, GRIK1, GPM6B, GAS7, HDAC4, IGSF9B, INSC, KALRN, LSAMP, MPPED2, MARK4, MAP1B, MBNL1, MEF2D, NRG1, NLGN1, NAV2, NR2E1, PRPS1, PCSK2, PPP2R5D, PCDHA10, PCDHA11, PCDHA2, PCDHA4, PCDHA5, PCDHA8, SEMA6A, SRRM4, SHOX2, SIGMAR1, SCN8A, TSHR, TMEM41B, TPP1, TMOD2, ZEB2,