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Fig. 2 | Nutrition & Metabolism

Fig. 2

From: The impact of ATP-binding cassette transporters on metabolic diseases

Fig. 2

ABC transporter-related signaling pathways. A: Inhibition of ABC transporters can lead to an increase in oxLDL (shown by dotted line). oxLDL can cause inflammation through the LOX-1/NF-κB pathway to induce ROS production. B: LPS can induce ABCA1 via the TLR4/GPS2/NF-κB pathway to upregulate the gene expression of ABCA1. C: The PKC/PI3-K/Akt/JNK/LXR/RXR pathway is positively correlated with the expression of ABCA1. D: CRH can inhibit the activation of LXR (shown by dotted line) via the CRHR1/PI3-K/Akt pathway. E: IGF-1 can induce the PI3-K/Akt/FOXO1 pathway to activate FOXO1 which can facilitate the transcription of ABCA1 and ABCG5/8. F: MAPK1 can induce the expression of ABCA1. H: Expression of ABC transporters can inhibit the activation of SREBP (shown by dotted line), which can reduce lipogenesis. Abbreviation: ABC: Adenosine triphosphate-binding cassette; oxLDL: Oxidized low-density lipoproteins; LOX-1: Lectin-like oxidized low-density lipoprotein receptor-1; ROS: Reactive oxygen species; LPS: Lipopolysaccharides; TLR4: Toll-like receptor 4; GPS2: G protein pathway suppressor 2; PKC: Protein kinase C; PI3-K: Phosphatidylinositol 3-kinase; Akt: Protein kinase B; JNK: C-Jun N-terminal kinases; LXR: Liver X receptor; RXR: Retinoid-X-receptor; CRH: Corticotropin-releasing hormone; CRHR1: Corticotropin-releasing hormone receptor 1; IGF-1: Insulin-like growth factor 1; FOXO1: Forkhead box protein O1; MAPK1: Mitogen-activated protein kinase 1; SREBP: Sterol regulatory element binding protein; PPAR: peroxisome proliferator-activated receptor

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