Author (year) | Country (Reference number) | Study design (Sex) | Participants numbers | Type and dose of Propolis administered | Duration (Mean age of subjects) | Outcome measures |
---|---|---|---|---|---|---|
Hesami S et al. (2019) [120] | Iran | Parallel RCT (M/F) | 62 type 2 diabetic patients | Propolis capsule (500 mg) 3 times a day | 8 weeks AGE (mean years (SD)): No information | S.R in Fructosamine level, the level of Ox-LDL S.I in catalase activity |
Giammarinaro E et al. (2018) [121] | Italy | Parallel RCT (M/F) | 40 Patients with gingivitis | Anti-oxidant gel formula contains propolis (dose not mentioned …) | 3 months AGE (mean years (SD)): No information | S.R in Salivary oxidative stress |
Javadi M et al. (2018) [122] | Iran | Parallel RCT (M) | 60 men with asthenospermia | 1500 mg (three capsules of 500 mg) | 12 weeks AGE (mean years (SD)): No information | S.R in MDA. S.I in total antioxidant capacity |
Gao W et al. (2018) [18] | China | Open-label CT study (M/F) | 61 type 2 diabetes patients | 1 capsule once daily each capsule: 900 mg | 18-week (59.1 years) | S.I in GSH, Total polyphenols, total flavonoids and serum levels of IL-6 and S.R in LDH N.S in FRAP, SOD, GSHPx, MDA, carbonyls and serum levels of TNF-α and IL-1β |
Zakerkish M et al. (2018) [81] | Iran | Parallel RCT (M/F) | 94 patients with type 2 diabetes mellitus | 2 capsules daily each capsule contain: 500 mg | 90 days (55.14) | S.R in TNF-α and hs-CRP |
Mujica V et al. (2017) [123] | Chile | Parallel RCT (M/F) | 67 patients with metabolic disorder | 15 drops of propolis 3% (Beepolis®)each time | 90 days (46.4 years) | S.I in GSH levels, HDL S R in TBARS levels |
Zhao L et al. (2016) [82] | China | Parallel RCT (M/F) | 65 type 2 diabetes patients | 1 capsule once daily each capsule: 900 mg | 18-week (60.1 years) | S.I in GSH and total polyphenols, serum IL-1β and IL-6 S.R in serum carbonyls and LDH and serum TNF-α N.S in FRAP, SOD, GSH-Px, MDA or Ox-LDL |
Afsharpour F et al. (2016) [35] | Iran | RCT(M/F) | 62 patient with type 2 diabetes mellitus | 3 capsules daily each capsule contain:500 mg | 8 weeks(50.43) | S.R in CRP and TNF-α level |
Fukuda T et al. (2015) [106] | Japan | RCT(M/F) | 80 patient with type 2 diabetes mellitus | 1 tablet once daily each tablet: 226.8 mg | 8 weeks(63.31) | N.S in serum levels of TNF-α, hs-CRP and IL-6 |
Khayyal MT. et al. (2002) [124] | Egypt | RCT(M/F) | 46 patients with mild to moderate asthma | 1 capsule once daily each capsule: 200 mg | 2 months | S.R in interleukin (IL)-6 and IL-8 and TNF-α S.I in The serum levels of IL-10 |